Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DMCPZYT)

Drug Name
CV-9201 Drug Info
Synonyms CV-9201-1; CV-9201-2; CV-9201-3; CV-9201-4; CV-9201-5; RNA-based vaccine (NY-ESO-1, MAGE-C1/CT7, MAGE-C2/CT10, NSCLC), CureVac
Indication
Disease Entry ICD 11 Status REF
Non-small-cell lung cancer 2C25.Y Phase 1/2 [1]
Cross-matching ID
TTD Drug ID
DMCPZYT

Molecule(s) Related to This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Apoptosis inhibitor survivin (BIRC5) TTTPU1G BIRC5_HUMAN Not Available [2]
Cancer/testis antigen 1 (NY-ESO-1) TTE5ITK CTG1B_HUMAN Not Available [2]
Cancer/testis antigen MAGE-C1/CT7 (MAGEC1) TT9M6NA MAGC1_HUMAN Not Available [3]
Melanoma-associated antigen C2 (MAGEC2) TTKGUEB MAGC2_HUMAN Not Available [2]
Oncotrophoblast glycoprotein 5T4 (TPBG) TT70MLA TPBG_HUMAN Not Available [2]

The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule Molecule Type Gene Name Liver Colon Kidney Small Intestine
Apoptosis inhibitor survivin (BIRC5) DTT BIRC5 3.945 5.647 3.263 5.957
Melanoma-associated antigen C2 (MAGEC2) DTT MAGEC2 5.915 4.65 4.67 5.394
Cancer/testis antigen MAGE-C1/CT7 (MAGEC1) DTT MAGEC1 4.833 5.146 4.907 4.858
Oncotrophoblast glycoprotein 5T4 (TPBG) DTT TPBG 5.278 7.52 7.518 7.012
Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease Non-small-cell lung cancer
ICD Disease Classification 2C25.Y
Molecule Name Molecule Type Gene Name p-value Fold-Change Z-score
Apoptosis inhibitor survivin (BIRC5) DTT BIRC5 1.67E-190 1.63 5.29
Melanoma-associated antigen C2 (MAGEC2) DTT MAGEC2 1.99E-21 0.08 0.43
Cancer/testis antigen MAGE-C1/CT7 (MAGEC1) DTT MAGEC1 5.09E-22 0.07 0.45
Oncotrophoblast glycoprotein 5T4 (TPBG) DTT TPBG 1.73E-130 1.07 3.46
Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1 ClinicalTrials.gov (NCT00923312) Trial of an RNActive-Derived Cancer Vaccine in Stage IIIB/IV Non Small Cell Lung Cancer (NSCLC). U.S. National Institutes of Health.
2 National Cancer Institute Drug Dictionary (drug id 648549).
3 National Cancer Institute Drug Dictionary (drug id 648549).