Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DMCV109)

• Drug Name: Etanercept Drug Info
• Synonyms: Etanercept (sciatica); Etanercept (sciatica), BioAssets Development; Etanercept (sciatica), Cephalon

Indication

Disease Entry	ICD 11	Status	REF
Arthritis	FA20	Approved	[1]
Psoriatic arthritis	FA21	Approved	[2]
Sciatica	ME84.3	Phase 3	[3]
Pemphigus vulgaris	EB40	Phase 2	[4]

• Cross-matching ID:
  TTD Drug ID: DMCV109
  VARIDT Drug ID: DR00437

Molecule(s) Related to This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Tumor necrosis factor (TNF)	TTF8CQI	TNFA_HUMAN	Modulator	[5]

The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule	Molecule Type	Gene Name	Liver	Colon	Kidney	Small Intestine
Tumor necrosis factor (TNF)	DTT	TNF	5.692	3.07	4.413	1.202

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

• The Studied Disease: Arthritis
• ICD Disease Classification: FA20

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
Tumor necrosis factor (TNF)	DTT	TNF	8.51E-01	0.05	0.27

References

• [1] Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services.
• [2] Etanercept and Methotrexate as Monotherapy or in Combination for Psoriatic Arthritis: Primary Results From a Randomized, Controlled Phase III Trial. Arthritis Rheumatol. 2019 Jul;71(7):1112-1124.
• [3] URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 6789).
• [4] ClinicalTrials.gov (NCT00135720) Study of Etanercept (Enbrel) in the Treatment of Pemphigus Vulgaris
• [5] The potential of biologics for the treatment of asthma. Nat Rev Drug Discov. 2012 Dec;11(12):958-72.