Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DMDC297)

• Drug Name: (R)-1-(4-iodo-2,5-dimethoxyphenyl)propan-2-amine Drug Info
• Synonyms: (R)-1-(4-Iodo-2,5-dimethoxyphenyl)propan-2-amine; CHEMBL134519; R-DOI; Lopac0_000478; GTPL157; (R)-DOI; SCHEMBL713061; ZINC2516053; PDSP2_001372; Benzeneethanamine, 4-iodo-2,5-dimethoxy-alpha-methyl-, (alphaR)-; BDBM50133231; PDSP1_001388; CCG-204569; NCGC00162167-01; AJ-36945; 82864-06-0; (2R)-1-(4-iodo-2,5-dimethoxyphenyl)propan-2-amine; (r)-1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane; (R)-2-(4-iodo-2,5-dimethoxyphenyl)-1-methylethylamine; (R)-2-(4-Iodo-2,5-dimethoxy-phenyl)-1-methyl-ethylamine; UNII-OOM10GW9UE

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

• Cross-matching ID:
  PubChem CID: 9840090
  TTD Drug ID: DMDC297

Molecule(s) Related to This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
5-HT 2A receptor (HTR2A)	TTJQOD7	5HT2A_HUMAN	Inhibitor	[1]

The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule	Molecule Type	Gene Name	Liver	Colon	Kidney	Small Intestine
5-HT 2A receptor (HTR2A)	DTT	HTR2A	4.84	4.904	4.652	4.129

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

• The Studied Disease: Discovery agent
• ICD Disease Classification: N.A.

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
5-HT 2A receptor (HTR2A)	DTT	HTR2A	1.68E-01	-0.3	-0.14
5-HT 2A receptor (HTR2A)	DTT	HTR2A	5.59E-01	0.15	0.21

References

• [1] Novel benzodifuran analogs as potent 5-HT2A receptor agonists with ocular hypotensive activity. Bioorg Med Chem Lett. 2007 Jun 1;17(11):2998-3002.