Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DMDLK9G)

• Drug Name: C-(1H-Indol-3-yl)-methylamine Drug Info
• Synonyms: (1H-Indol-3-yl)methanamine; 22259-53-6; 1H-Indole-3-methanamine; 3-(aminomethyl)indole; 1H-indol-3-ylmethanamine; Indol-3-ylmethylamine; 1H-Indol-3-ylmethylamine; 3-aminomethylindole; CHEBI:65009; CHEMBL6509; C-(1H-Indol-3-yl)-methylamine; 3-Indolylmethylamine; Indole-3-methanamine; 3-Aminomethyl indole; AC1LAOER; 3-(aminomethyl) indole; 1H-indol-3-ylmethyl amine; Indole, 3-(aminomethyl)-; 1H-indol-3-yl-methyl-amine; SCHEMBL701395; AC1Q548H; C-(1H-indol-3-yl)methylamine; 1-(1H-indol-3-yl)methanamine; JXYGLMATGAAIBU-UHFFFAOYSA-

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

• Cross-matching ID:
  PubChem CID: 472107
  ChEBI ID: CHEBI:65009
  CAS Number: CAS 22259-53-6
  TTD Drug ID: DMDLK9G

Molecule(s) Related to This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Monoamine oxidase type A (MAO-A)	TT3WG5C	AOFA_HUMAN	Inhibitor	[1]
Monoamine oxidase type B (MAO-B)	TTGP7BY	AOFB_HUMAN	Inhibitor	[1]

The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule	Molecule Type	Gene Name	Liver	Colon	Kidney	Small Intestine
Monoamine oxidase type B (MAO-B)	DTT	MAOB	9.367	6.907	8.237	8.409
Monoamine oxidase type A (MAO-A)	DTT	MAOA	7.207	8.159	9.043	7.711

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

• The Studied Disease: Discovery agent
• ICD Disease Classification: N.A.

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
Monoamine oxidase type B (MAO-B)	DTT	MAOB	2.65E-02	1.12E-02	0.07
Monoamine oxidase type A (MAO-A)	DTT	MAOA	8.14E-01	0.05	0.1

References

• [1] Binding of beta-carbolines at imidazoline I2 receptors: a structure-affinity investigation. Bioorg Med Chem Lett. 2004 Feb 23;14(4):999-1002.