Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DMENF5K)

Drug Name
Liatermin Drug Info
Synonyms RGDNF; GDNF, Amgen; Glial derived neurotrophic factor, Amgen/Medtronic
Indication
Disease Entry ICD 11 Status REF
Lateral sclerosis 8B61 Phase 1/2 [1]
Cross-matching ID
TTD Drug ID
DMENF5K

Molecule(s) Related to This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Glial cell line-derived neurotrophic factor (GDNF) TTF23ML GDNF_HUMAN Modulator [2]

The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule Molecule Type Gene Name Liver Colon Kidney Small Intestine
Glial cell line-derived neurotrophic factor (GDNF) DTT GDNF 2.7 2.888 4.263 2.459
Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

ICD Disease Classification 08 Disease of the nervous system
Disease Class ICD-11: 8A00 Parkinsonism
The Studied Tissue Cervical spinal cord
The Studied Disease Lateral sclerosis [ICD-11:8A00.0]
Molecule Name Molecule Type Gene Name p-value Fold-Change Z-score
Glial cell line-derived neurotrophic factor (GDNF) DTT GDNF 2.29E-01 0.08 0.31
Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1 ClinicalTrials.gov (NCT00111982) Trial of Extended Treatment With Liatermin (r-metHuGDNF) Administered by Continuous Intraputaminal (IPu)Infusion to Subjects With Idiopathic Parkinson's Disease Who Have Completed a Previous Trial of Liatermin. U.S. National Institutes of Health.
2 Interpreting expression profiles of cancers by genome-wide survey of breadth of expression in normal tissues. Genomics 2005 Aug;86(2):127-41.