Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DMEU86T)

Drug Name
ACT017 Drug Info
Indication
Disease Entry ICD 11 Status REF
Cerebral ischemia 8B11 Phase 1/2 [1]
Cross-matching ID
TTD Drug ID
DMEU86T

Molecule(s) Related to This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Platelet glycoprotein VI (GP6) TTTJUVZ GPVI_HUMAN Inhibitor [2]

The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule Molecule Type Gene Name Liver Colon Kidney Small Intestine
Platelet glycoprotein VI (GP6) DTT GP6 5.731 5.24 4.888 6.127
Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease Cerebral ischemia
ICD Disease Classification 8B11
Molecule Name Molecule Type Gene Name p-value Fold-Change Z-score
Platelet glycoprotein VI (GP6) DTT GP6 3.57E-01 0.03 0.26
Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1 ClinicalTrials.gov (NCT03803007) Acute Ischemic Stroke Interventional Study (ACTIMIS). U.S. National Institutes of Health.
2 Safety and Tolerability, Pharmacokinetics, and Pharmacodynamics of ACT017, an Antiplatelet GPVI (Glycoprotein VI) Fab. Arterioscler Thromb Vasc Biol. 2019 May;39(5):956-964.