Details of the Drug

General Information of Drug (ID: DMEU86T)

Drug Name
ACT017
Indication
Disease Entry ICD 11 Status REF
Cerebral ischemia 8B11 Phase 1/2 [1]
Drug Type
Small molecular drug
Cross-matching ID
TTD ID
DPG5T9

Molecular Interaction Atlas of This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Platelet glycoprotein VI (GP6) TTTJUVZ GPVI_HUMAN Inhibitor [2]
Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This Drug

Molecular Expression Atlas of This Drug

The Studied Disease Cerebral ischemia
ICD Disease Classification 8B11
Molecule Name Molecule Type Gene Name p-value Fold-Change Z-score
Platelet glycoprotein VI (GP6) DTT GP6 3.57E-01 0.03 0.26
Molecular Expression Atlas (MEA) Jump to Detail Molecular Expression Atlas of This Drug

References

1 ClinicalTrials.gov (NCT03803007) Acute Ischemic Stroke Interventional Study (ACTIMIS). U.S. National Institutes of Health.
2 Safety and Tolerability, Pharmacokinetics, and Pharmacodynamics of ACT017, an Antiplatelet GPVI (Glycoprotein VI) Fab. Arterioscler Thromb Vasc Biol. 2019 May;39(5):956-964.