Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DMFDK4N)

Drug Name

1',2',3',6'-Tetrahydro-[2,4']bipyridinyl Drug Info

Synonyms

1',2',3',6'-Tetrahydro-[2,4']bipyridinyl; 50461-51-3; CHEMBL278934; 1',2',3',6'-tetrahydro-2,4'-bipyridine; 2-(1,2,3,6-tetrahydropyridin-4-yl)pyridine; 2,4'-Bipyridine, 1',2',3',6'-tetrahydro-; SCHEMBL169400; CTK4J2646; DTXSID50569450; IVRPDZRVHKIBBG-UHFFFAOYSA-N; ZINC19811349; BDBM50026630; AKOS000205268

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

PubChem CID: 15166842
CAS Number: CAS 50461-51-3
TTD Drug ID: DMFDK4N

Molecule(s) Related to This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Adrenergic receptor alpha-1A (ADRA1A)	TTNGILX	ADA1A_HUMAN	Inhibitor	[1]
Adrenergic receptor alpha-1D (ADRA1D)	TT34BHT	ADA1D_HUMAN	Inhibitor	[1]
Adrenergic receptor alpha-2A (ADRA2A)	TTWG9A4	ADA2A_HUMAN	Inhibitor	[1]
Adrenergic receptor alpha-2B (ADRA2B)	TTWM4TY	ADA2B_HUMAN	Inhibitor	[1]

------------------------------------------------------------------------------------

The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule	Molecule Type	Gene Name	Liver	Colon	Kidney	Small Intestine
Adrenergic receptor alpha-1A (ADRA1A)	DTT	ADRA1A	3.154	3.853	4.129	2.963

Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease

Discovery agent

ICD Disease Classification

N.A.

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
Adrenergic receptor alpha-1A (ADRA1A)	DTT	ADRA1A	9.43E-01	-0.03	-0.25

Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1	Adrenoceptor and tetrabenazine antagonism activities of some pyridinyltetrahydropyridines. J Med Chem. 1984 Sep;27(9):1182-5.