Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DMFUNL1)

Drug Name

Pyridoxine-5'-Phosphate Drug Info

Synonyms

Pyridoxine phosphate; Pyridoxine 5-phosphate; pyridoxine-5'-phosphate; Pyridoxyl-5-phosphate; Pyridoxol 5-phosphate; 447-05-2; Pyridoxol 5'-phosphate; UNII-RG20W8WYLS; 5-Hydroxy-4-(hydroxymethyl)-6-methyl-3-pyridylmethyl dihydrogen phosphate; PYRIDOXINE 5'-PHOSPHATE; EINECS 207-179-6; NSC 83119; RG20W8WYLS; BRN 0233737; Pyridoxol, 5-(dihydrogen phosphate); [5-hydroxy-4-(hydroxymethyl)-6-methylpyridin-3-yl]methyl dihydrogen phosphate; pyridoxine-P; pyridoxine-5P; 3,4-Pyridinedimethanol, 5-hydroxy-6-methyl-, alpha(3)-(dihydrog

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

PubChem CID: 1055
ChEBI ID: CHEBI:28803
CAS Number: CAS 447-05-2
TTD Drug ID: DMFUNL1
INTEDE Drug ID: DR1373

Molecule(s) Related to This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Bacterial Pyridoxal phosphate biosynthetic pdxJ (Bact pdxJ)	TTHB48R	PDXJ_ECOLI	Inhibitor	[1]
Ornithine decarboxylase (ODC1)	TTUMGNO	DCOR_HUMAN	Inhibitor	[1]

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Drug-Metabolizing Enzyme (DME)

DME Name	DME ID	UniProt ID	Highest Status	REF
Pyridoxamine-phosphate oxidase (PNPO)	DE3Z1RA	PNPO_HUMAN	Investigative	[2]

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The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule	Molecule Type	Gene Name	Liver	Colon	Kidney	Small Intestine
Ornithine decarboxylase (ODC1)	DTT	ODC1	9.956	8.598	9.482	8.752
Pyridoxamine-phosphate oxidase (PNPO)	DME	PNPO	7.731	6.545	7.291	7.208

Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease

Discovery agent

ICD Disease Classification

N.A.

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
Ornithine decarboxylase (ODC1)	DTT	ODC1	5.20E-35	1.58	2.43
Pyridoxamine-phosphate oxidase (PNPO)	DME	PNPO	1.18E-02	6.97E-02	2.83E-01

Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1	How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6.
2	Pyridoxine 5'-phosphate oxidase is a novel therapeutic target and regulated by the TGF-beta signalling pathway in epithelial ovarian cancer. Cell Death Dis. 2017 Dec 13;8(12):3214.