Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DMG21PZ)

Drug Name

Di(2,6-diisopropylphenol) Drug Info

Synonyms

3,3',5,5'-Tetraisopropylbiphenyl-4,4'-diol; 2416-95-7; Dipropofo; UNII-H9GE6HX42A; di(2,6-diisopropylphenol); H9GE6HX42A; CHEMBL478518; 3,3',5,5'-Tetrakis(1-methylethyl)biphenyl-4,4'-diol; AK-51092; 3,3',5,5'-Tetraisopropyl-[1,1'-biphenyl]-4,4'-diol; Propofol related compound A; Dipropofol; Propofol related compound A [USP]; Propofol specified impurity E [EP]; Propofol Impurity E; Propofol related compound A RS [USP]; 3,3',5,5'-Tetraisopropyl-4,4'-dihydroxybiphenyl; SCHEMBL275427; CTK4F3066; DTXSID30178867

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

PubChem CID: 11602828
CAS Number: CAS 2416-95-7
TTD Drug ID: DMG21PZ

Molecule(s) Related to This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Carbonic anhydrase II (CA-II)	TTANPDJ	CAH2_HUMAN	Inhibitor	[1]

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The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule	Molecule Type	Gene Name	Liver	Colon	Kidney	Small Intestine
Carbonic anhydrase II (CA-II)	DTT	CA2	8.796	10.933	9.395	9.819

Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease

Discovery agent

ICD Disease Classification

N.A.

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
Carbonic anhydrase II (CA-II)	DTT	CA2	7.95E-08	0.52	0.33

Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1	Carbonic anhydrase inhibitors. Inhibition of human erythrocyte isozymes I and II with a series of antioxidant phenols. Bioorg Med Chem. 2009 Apr 15;17(8):3207-11.