Details of the Drug-Related molecule(s) Expression Atlas

HIMBACINE Drug Info

Himbacine; UNII-M17C7V122D; NSC 23969; HIMBAFCINE; CHEMBL277642; CHEBI:5720; (+)-himbacine; M17C7V122D; 6879-74-9; Naphtho(2,3-c)furan-1(3H)-one, decahydro-4-(2-(1,6-dimethyl-2-piperidinyl)ethenyl)-3-methyl-,(3S-(3-alpha,3a-alpha,4-beta(1E,2(2R*,6S*)),4a-beta,8a-alpha,9a-alpha))-; AC1O5LBZ; GTPL324; SCHEMBL194692; BDBM50076089; CCG-208219; NCGC00163249-01; LS-95329; SR-05000002338; SR-05000002338-2; 4-[2-(1,6-Dimethyl-piperidin-2-yl)-vinyl]-3-methyl-decahydro-naphtho[2,3-c]furan-1-one

Cross-matching ID

PubChem CID

6436265

ChEBI ID

CHEBI:5720

CAS Number

CAS 6879-74-9

TTD Drug ID

DMGAKD8

General Information of Drug (ID: DMGAKD8)

Molecule(s) Related to This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Muscarinic acetylcholine receptor M1 (CHRM1)	TTZ9SOR	ACM1_HUMAN	Inhibitor	[1]
Muscarinic acetylcholine receptor M2 (CHRM2)	TTYEG6Q	ACM2_HUMAN	Inhibitor	[1]

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The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
Muscarinic acetylcholine receptor M1 (CHRM1)	DTT	CHRM1	8.42E-02	-0.38	-0.24
Muscarinic acetylcholine receptor M1 (CHRM1)	DTT	CHRM1	2.55E-01	0.14	0.37
Muscarinic acetylcholine receptor M2 (CHRM2)	DTT	CHRM2	8.42E-02	-0.38	-0.24
Muscarinic acetylcholine receptor M2 (CHRM2)	DTT	CHRM2	2.55E-01	0.14	0.37

Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1	Himbacine analogs as muscarinic receptor antagonists--effects of tether and heterocyclic variations. Bioorg Med Chem Lett. 2004 Aug 2;14(15):3967-70.