Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DMGZ3DR)

Drug Name
NT-3 Drug Info
Synonyms Neurotrophin-3; NT-3, Amgen-Regeneron Partners; NT-3, Amgen/ Regeneron; Neurotrophin-3, Amgen-Regeneron Partners; Neurotrophin-3, Amgen/ Regeneron
Indication
Disease Entry ICD 11 Status REF
Constipation DD91.1 Discontinued in Phase 2 [1]
Cross-matching ID
TTD Drug ID
DMGZ3DR

Molecule(s) Related to This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Neurotrophin-3 (NTF3) TTZHKV9 NTF3_HUMAN Modulator [2]

The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule Molecule Type Gene Name Liver Colon Kidney Small Intestine
Neurotrophin-3 (NTF3) DTT NTF3 4.567 4.009 4.256 4.053
Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease Constipation
ICD Disease Classification DD91.1
Molecule Name Molecule Type Gene Name p-value Fold-Change Z-score
Neurotrophin-3 (NTF3) DTT NTF3 5.49E-01 -0.01 -0.05
Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 5033).
2 NT-3. Takeda/Regeneron/Amgen. IDrugs. 2001 Jul;4(7):820-4.