Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DMHTPSF)

Drug Name

PNU-22394 Drug Info

Synonyms

PNU-22394; CHEMBL6557; 6-methyl-1,2,3,4,5,6-hexahydroazepino[4,5-b]indole; 6-Methyl-1,2,3,4,5,6-hexahydro-azepino[4,5-b]indole; AC1L1DHJ; SCHEMBL5364550; CHEBI:92297; ZINC2018607; BDBM50130095; BRD-K16551401-003-02-6; BRD-K16551401-003-01-8; 6-methyl-2,3,4,5-tetrahydro-1H-azepino[4,5-b]indole

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

PubChem CID: 27559
ChEBI ID: CHEBI:92297
CAS Number: CAS 15923-78-1
TTD Drug ID: DMHTPSF

Molecule(s) Related to This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Monoamine oxidase type A (MAO-A)	TT3WG5C	AOFA_HUMAN	Inhibitor	[1]
Monoamine oxidase type B (MAO-B)	TTGP7BY	AOFB_HUMAN	Inhibitor	[1]

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The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule	Molecule Type	Gene Name	Liver	Colon	Kidney	Small Intestine
Monoamine oxidase type B (MAO-B)	DTT	MAOB	9.367	6.907	8.237	8.409
Monoamine oxidase type A (MAO-A)	DTT	MAOA	7.207	8.159	9.043	7.711

Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease

Discovery agent

ICD Disease Classification

N.A.

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
Monoamine oxidase type B (MAO-B)	DTT	MAOB	2.65E-02	1.12E-02	0.07
Monoamine oxidase type A (MAO-A)	DTT	MAOA	8.14E-01	0.05	0.1

Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1	Binding of beta-carbolines at imidazoline I2 receptors: a structure-affinity investigation. Bioorg Med Chem Lett. 2004 Feb 23;14(4):999-1002.