Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DMIFOXE)

Drug Name

1,4-Dithiothreitol Drug Info

Synonyms

Cleland's reagent; Dithiothreitol; 1,4-Dithiothreitol; Dithiotreitol; 1,4-Dimercaptobutane-2,3-diol; dl-Dithiothreitol; rac-Dithiothreitol; Cleland reagent; 7634-42-6; 1,4-disulfanylbutane-2,3-diol; Clelands reagent; Sputolysin; DL-threo-1,4-Dimercapto-2,3-butanediol; 1,4-dimercapto-2,3-butanediol; 3483-12-3; 2,3-Butanediol, 1,4-dimercapto-; Threitol, 1,4-dithio-; 1,4-bis(sulfanyl)butane-2,3-diol; trans-1,4-Dimercaptobutane-2,3-diol; L-1,4-Dithiothreitol; L-Dithiothreitol; CHEBI:18320; 1,4-Bissulfanylbutane-2,3-diol

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

PubChem CID: 19001
ChEBI ID: CHEBI:18320
CAS Number: CAS 7634-42-6
TTD Drug ID: DMIFOXE

Molecule(s) Related to This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Candida Thymidylate synthase (Candi TMP1)	TTU6BFZ	TYSY_CANAL	Inhibitor	[1]
HMG-CoA reductase (HMGCR)	TTPADOQ	HMDH_HUMAN	Inhibitor	[1]
Rotamase B (PPIB)	TT6ZFQ4	PPIB_HUMAN	Inhibitor	[1]

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The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule	Molecule Type	Gene Name	Liver	Colon	Kidney	Small Intestine
HMG-CoA reductase (HMGCR)	DTT	HMGCR	6.357	6.256	5.17	6.85

Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease

Discovery agent

ICD Disease Classification

N.A.

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
HMG-CoA reductase (HMGCR)	DTT	HMGCR	1.01E-05	0.65	1.53

Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1	How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6.