Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DMIOFQE)

Drug Name
SOMATOSTATIN Drug Info
Synonyms
51110-01-1; Somiaton; Panhibin; Aminopan; Somatostatin acetate; SRIF; Somatotropin release-inhibiting factor; Somatotropin release-inhibiting hormone; Growth hormone release-inhibiting factor; CCRIS 7071; EINECS 256-969-7; Growth hormone release-inhibiting hormone; AY 24910; Growth hormone release inhibiting factor; Somatostatin 1-14; Ala-Gly-Cys-Lys-Asn-Phe-Phe-Trp-Lys-Thr-Phe-Thr-Ser-Cys; NCGC00181005-01; 61950-59-2; [D-Trp8]-SOMATOSTATIN; SCHEMBL3046327
Indication
Disease Entry ICD 11 Status REF
Acromegaly 5A60.0 Approved [1]
Carcinoid syndrome 5B10 Approved [2]
Discovery agent N.A. Investigative [3]
Cross-matching ID
PubChem CID
16129706
ChEBI ID
CHEBI:64628
CAS Number
CAS 38916-34-6
TTD Drug ID
DMIOFQE

Molecule(s) Related to This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Opioid receptor delta (OPRD1) TT27RFC OPRD_HUMAN Inhibitor [4]
Opioid receptor mu (MOP) TTKWM86 OPRM_HUMAN Inhibitor [4]
Somatostatin receptor type 1 (SSTR1) TTIND6G SSR1_HUMAN Inhibitor [3]
Somatostatin receptor type 2 (SSTR2) TTZ6T9E SSR2_HUMAN Inhibitor [3]
Somatostatin receptor type 3 (SSTR3) TTJX3UE SSR3_HUMAN Inhibitor [3]
Somatostatin receptor type 4 (SSTR4) TTAE1BR SSR4_HUMAN Inhibitor [3]
Somatostatin receptor type 5 (SSTR5) TT2BC4G SSR5_HUMAN Inhibitor [3]

The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule Molecule Type Gene Name Liver Colon Kidney Small Intestine
Somatostatin receptor type 2 (SSTR2) DTT SSTR2 4.703 4.931 5.624 5.184
Opioid receptor mu (MOP) DTT OPRM1 4.548 5.062 4.652 4.776
Somatostatin receptor type 3 (SSTR3) DTT SSTR3 3.087 2.07 3.263 2.036
Somatostatin receptor type 1 (SSTR1) DTT SSTR1 5.588 3.392 4.087 4.009
Somatostatin receptor type 4 (SSTR4) DTT SSTR4 5.615 5.998 3.7 6.158
Somatostatin receptor type 5 (SSTR5) DTT SSTR5 2.104 0.585 0.585 2.585
Opioid receptor delta (OPRD1) DTT OPRD1 2.848 2.263 1.536 2
Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease Acromegaly
ICD Disease Classification 5A60.0
Molecule Name Molecule Type Gene Name p-value Fold-Change Z-score
Somatostatin receptor type 2 (SSTR2) DTT SSTR2 9.79E-07 -0.38 -0.65
Somatostatin receptor type 3 (SSTR3) DTT SSTR3 2.40E-04 -0.09 -0.56
Somatostatin receptor type 1 (SSTR1) DTT SSTR1 2.39E-14 -0.6 -0.83
Somatostatin receptor type 4 (SSTR4) DTT SSTR4 1.12E-02 -0.07 -0.32
Somatostatin receptor type 5 (SSTR5) DTT SSTR5 2.74E-01 -0.04 -0.26
Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1 A Pituitary Society update to acromegaly management guidelines. Pituitary. 2021 Feb;24(1):1-13.
2 Carcinoid-syndrome: recent advances, current status and controversies. Curr Opin Endocrinol Diabetes Obes. 2018 Feb;25(1):22-35.
3 Discovery of iodinated somatostatin analogues selective for hsst2 and hsst5 with excellent inhibition of growth hormone and prolactin release from ... J Med Chem. 2005 Oct 20;48(21):6643-52.
4 Design and synthesis of conformationally constrained somatostatin analogues with high potency and specificity for mu opioid receptors. J Med Chem. 1986 Nov;29(11):2370-5.