Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DMJ7I4U)

Drug Name

Sodium phenylaminomethanesulfonate Drug Info

Synonyms

Sodium anilinomethanesulfonate; Sodium anilinomethanesulphonate; Methanesulfonic acid, (phenylamino)-, monosodium salt; 26021-90-9; Aniline-N-methylsulfonic acid,Na salt; Methanesulfonic acid, 1-(phenylamino)-, sodium salt (1:1); Anilinomethanesulfonate sodium salt; Anilinomethanesulfonic acid, sodium salt; W-110647; (Phenylamino)methanesulfonic acid, sodium salt; Phenylaminomethanesulfonic acid, monosodium salt; Sodium phenylaminomethanesulfonate; EINECS 247-417-6; NSC 57030; Anilinomethanesulfonic acid, monosodium salt

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

PubChem CID: 23680200
CAS Number: CAS 26021-90-9
TTD Drug ID: DMJ7I4U

Molecule(s) Related to This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Carbonic anhydrase IX (CA-IX)	TT2LVK8	CAH9_HUMAN	Inhibitor	[1]
Carbonic anhydrase XII (CA-XII)	TTSYM0R	CAH12_HUMAN	Inhibitor	[1]

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The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule	Molecule Type	Gene Name	Liver	Colon	Kidney	Small Intestine
Carbonic anhydrase XII (CA-XII)	DTT	CA12	6.015	9.06	10.222	5.773
Carbonic anhydrase IX (CA-IX)	DTT	CA9	5.04	6.156	4.609	6.756

Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease

Discovery agent

ICD Disease Classification

N.A.

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
Carbonic anhydrase XII (CA-XII)	DTT	CA12	3.29E-21	1.27	1.02
Carbonic anhydrase IX (CA-IX)	DTT	CA9	1.12E-10	-0.03	-0.09

Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1	Carbonic anhydrase inhibitors. Diazenylbenzenesulfonamides are potent and selective inhibitors of the tumor-associated isozymes IX and XII over the... Bioorg Med Chem. 2009 Oct 15;17(20):7093-9.