Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DMLDUJ1)

Drug Name
KURAIDIN Drug Info
Synonyms KURAIDIN; kuraridin; CHEMBL243362; PIAPWPAWQGDOMN-SXAWMYDMSA-N; ZINC13817033
Indication
Disease Entry ICD 11 Status REF
Discovery agent N.A. Investigative [1]
Cross-matching ID
PubChem CID
44428631
CAS Number
CAS 34981-25-4
TTD Drug ID
DMLDUJ1
VARIDT Drug ID
DR00952

Molecule(s) Related to This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Phosphodiesterase 3A (PDE3A) TT06AWU PDE3A_HUMAN Inhibitor [1]
Phosphodiesterase 4A (PDE4A) TTZ97H5 PDE4A_HUMAN Inhibitor [1]
Phosphodiesterase 4B (PDE4B) TTVIAT9 PDE4B_HUMAN Inhibitor [1]
Phosphodiesterase 5A (PDE5A) TTJ0IQB PDE5A_HUMAN Inhibitor [1]
SLC5A2 messenger RNA (SLC5A2 mRNA) TTF8JAT SC5A2_HUMAN Inhibitor [2]
Sodium/glucose cotransporter 1 (SGLT1) TT2UE56 SC5A1_HUMAN Inhibitor [2]

The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule Molecule Type Gene Name Liver Colon Kidney Small Intestine
Phosphodiesterase 4A (PDE4A) DTT PDE4A 4.1 2.787 2.379 3.433
Phosphodiesterase 4B (PDE4B) DTT PDE4B 5.261 3.863 4.256 5.217
Phosphodiesterase 5A (PDE5A) DTT PDE5A 3.632 3 3.632 4.271
SLC5A2 messenger RNA (SLC5A2 mRNA) DTT SLC5A2 5.466 5.271 7.359 3.573
Sodium/glucose cotransporter 1 (SGLT1) DTT SLC5A1 6.42 6.477 5.85 10.555
Phosphodiesterase 3A (PDE3A) DTT PDE3A 4.717 6.087 5.051 5.051
Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease Discovery agent
ICD Disease Classification N.A.
Molecule Name Molecule Type Gene Name p-value Fold-Change Z-score
Phosphodiesterase 4A (PDE4A) DTT PDE4A 9.26E-01 -3.01E-03 -0.01
Phosphodiesterase 4B (PDE4B) DTT PDE4B 2.75E-01 -0.13 -0.3
Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1 A prenylated flavonol, sophoflavescenol: a potent and selective inhibitor of cGMP phosphodiesterase 5. Bioorg Med Chem Lett. 2002 Sep 2;12(17):2313-6.
2 Na+-glucose cotransporter (SGLT) inhibitory flavonoids from the roots of Sophora flavescens. Bioorg Med Chem. 2007 May 15;15(10):3445-9.