Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DMLQZGJ)

Drug Name

CL-385004 Drug Info

Synonyms

CL-385004; UNII-YS11IQJ45S; YS11IQJ45S; CHEMBL300946; SCHEMBL5738957; BDBM50078663; Benzamide, 5-fluoro-2-methyl-N-(5-(5H-pyrrolo(2,1-C)(1,4)benzodiazepin-10(11H)-ylcarbonyl)-2-pyridinyl)-; 180416-31-3; L015160

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

PubChem CID: 9954905
CAS Number: CAS 180416-31-3
TTD Drug ID: DMLQZGJ

Molecule(s) Related to This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Vasopressin V1a receptor (V1AR)	TT4TFGN	V1AR_HUMAN	Antagonist	[1]
Vasopressin V2 receptor (V2R)	TTK8R02	V2R_HUMAN	Antagonist	[1]

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The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule	Molecule Type	Gene Name	Liver	Colon	Kidney	Small Intestine
Vasopressin V1a receptor (V1AR)	DTT	AVPR1A	4.689	3.609	4.591	3.878

Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease

Discovery agent

ICD Disease Classification

N.A.

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
Vasopressin V1a receptor (V1AR)	DTT	AVPR1A	8.89E-04	-0.12	-0.34

Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1	Nonpeptide vasopressin receptor antagonists: development of selective and orally active V1a, V2 and V1b receptor ligands. Prog Brain Res. 2002;139:197-210.