Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DMMIAXO)

Drug Name

Betamethasone Valerate Drug Info

Synonyms

Beta-val; Betaderm; Betatrex; Dermabet; Valnac

Indication

Disease Entry	ICD 11	Status	REF
Dermatological disease	DA24.Y	Approved	[1]

Cross-matching ID

Molecule(s) Related to This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Glucocorticoid receptor (NR3C1)	TTYRL6O	GCR_HUMAN	Modulator	[2]

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Drug-Metabolizing Enzyme (DME)

DME Name	DME ID	UniProt ID	Highest Status	REF
Cytochrome P450 3A4 (CYP3A4)	DE4LYSA	CP3A4_HUMAN	Approved	[3]
Corticosteroid 11-beta-dehydrogenase 2 (HSD11B2)	DEDH7FP	DHI2_HUMAN	Approved	[4]

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The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule	Molecule Type	Gene Name	Liver	Colon	Kidney	Small Intestine
Glucocorticoid receptor (NR3C1)	DTT	NR3C1	7.153	7.278	7.017	7.331
Corticosteroid 11-beta-dehydrogenase 2 (HSD11B2)	DME	HSD11B2	2.7	9.856	9.113	6.857
Cytochrome P450 3A4 (CYP3A4)	DME	CYP3A4	11.692	6.58	4.984	9.089

Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease

Dermatological disease

ICD Disease Classification

DA24.Y

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
Corticosteroid 11-beta-dehydrogenase 2 (HSD11B2)	DME	HSD11B2	2.15E-01	-2.26E-01	-6.33E-01
Cytochrome P450 3A4 (CYP3A4)	DME	CYP3A4	9.85E-01	2.24E-02	7.33E-02

Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1	Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015
2	Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services.
3	Studies on Drug Interactions between CYP3A4 Inhibitors and Glucocorticoids.
4	Metabolism of synthetic steroids by the human placenta. Placenta. 2007 Jan;28(1):39-46.