Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DMN4BIA)

Drug Name
KN-38-7271 Drug Info
Synonyms Cannabinoid 1/2 receptor agonists (cerebrovascular ischemia/pain), Bayer; Cannabinoid 1/2 receptor agonists (traumatic brain injury/stroke), KeyNeurotek
Indication
Disease Entry ICD 11 Status REF
Ischemia 8B10-8B11 Discontinued in Phase 2 [1]
Cross-matching ID
TTD Drug ID
DMN4BIA

Molecule(s) Related to This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Cannabinoid receptor 1 (CB1) TT6OEDT CNR1_HUMAN Modulator [2]
Cannabinoid receptor 2 (CB2) TTMSFAW CNR2_HUMAN Modulator [2]

The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule Molecule Type Gene Name Liver Colon Kidney Small Intestine
Cannabinoid receptor 2 (CB2) DTT CNR2 7.037 6.733 6.944 7.163
Cannabinoid receptor 1 (CB1) DTT CNR1 2.907 4.667 2.982 3.678
Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease Ischemia
ICD Disease Classification 8B10-8B11
Molecule Name Molecule Type Gene Name p-value Fold-Change Z-score
Cannabinoid receptor 1 (CB1) DTT CNR1 5.59E-02 -0.22 -0.45
Cannabinoid receptor 1 (CB1) DTT CNR1 7.68E-01 -0.06 -0.46
Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1 Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800014615)
2 BAY 38-7271: a novel highly selective and highly potent cannabinoid receptor agonist for the treatment of traumatic brain injury.CNS Drug Rev.2003 Winter;9(4):343-58.