Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DMNR3YL)

Drug Name

(+/-)-2-Phenylthiomorpholine Drug Info

Synonyms

2-phenylthiomorpholine; 77082-31-6; 2-PHENYL-THIOMORPHOLINE; CHEMBL608438; Thiomorpholine,2-phenyl-; (+/-)-2-Phenylthiomorpholine; AC1NMBWZ; AC1Q1ICC; Thiomorpholine, 2-phenyl-; SCHEMBL1636929; CTK5E3816; DTXSID20407436; MolPort-001-791-006; SRYHBJDVLOEJNP-UHFFFAOYSA-N; 2-Phenyl-thiomorpholine, AldrichCPR; BDBM50307369; AKOS006230101; MCULE-8074427790; QC-5067; NE56940; KB-69531; EN300-80273

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

PubChem CID: 5004199
CAS Number: CAS 77082-31-6
TTD Drug ID: DMNR3YL

Molecule(s) Related to This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Monoamine oxidase type A (MAO-A)	TT3WG5C	AOFA_HUMAN	Inhibitor	[1]
Monoamine oxidase type B (MAO-B)	TTGP7BY	AOFB_HUMAN	Inhibitor	[1]

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The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule	Molecule Type	Gene Name	Liver	Colon	Kidney	Small Intestine
Monoamine oxidase type B (MAO-B)	DTT	MAOB	9.367	6.907	8.237	8.409
Monoamine oxidase type A (MAO-A)	DTT	MAOA	7.207	8.159	9.043	7.711

Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease

Discovery agent

ICD Disease Classification

N.A.

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
Monoamine oxidase type B (MAO-B)	DTT	MAOB	2.65E-02	1.12E-02	0.07
Monoamine oxidase type A (MAO-A)	DTT	MAOA	8.14E-01	0.05	0.1

Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1	2-Arylthiomorpholine derivatives as potent and selective monoamine oxidase B inhibitors. Bioorg Med Chem. 2010 Feb 15;18(4):1388-95.