General Information of Drug (ID: DMO7920)

Drug Name
AM-831 Drug Info
Synonyms
199330-66-0; METHYL 4-AMINOTETRAHYDRO-2H-PYRAN-4-CARBOXYLATE HYDROCHLORIDE; methyl 4-aminooxane-4-carboxylate hydrochloride; METHYL 4-AMINOTETRAHYDROPYRAN-4-CARBOXYLATE HCL; methyl 4-aminotetrahydropyran-4-carboxylate hydrochloride; 2H-Pyran-4-carboxylic acid, 4-aminotetrahydro-, methyl ester, hydrochloride (1:1); SCHEMBL1818830; MolPort-009-013-807; VNPBPEQYIQVYDP-UHFFFAOYSA-N; AM831; KS-000008CU; SBB091929; AKOS025147281; PB10899; AS-36521; DB-065487; CS-0049053; FT-0768000; Q-1506; methyl 4-aminooxane-4-carboxylate,hydroch
Indication
Disease Entry ICD 11 Status REF
Schizophrenia 6A20 Discontinued in Phase 1 [1]
Cross-matching ID
PubChem CID
43811077
TTD Drug ID
DMO7920

Molecule(s) Related to This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
5-HT 2A receptor (HTR2A) TTJQOD7 5HT2A_HUMAN Agonist [2]
Dopamine D2 receptor (D2R) TTEX248 DRD2_HUMAN Agonist [2]
Muscarinic acetylcholine receptor M5 (CHRM5) TTH18TF ACM5_HUMAN Agonist [2]

The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule Molecule Type Gene Name Liver Colon Kidney Small Intestine
5-HT 2A receptor (HTR2A) DTT HTR2A 4.84 4.904 4.652 4.129
Dopamine D2 receptor (D2R) DTT DRD2 5.345 5.634 5.789 5.901
Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease Schizophrenia
ICD Disease Classification 6A20
Molecule Name Molecule Type Gene Name p-value Fold-Change Z-score
Dopamine D2 receptor (D2R) DTT DRD2 2.50E-02 -0.08 -0.49
Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1 Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800016551)
2 Clinical pipeline report, company report or official report of Avarx.