Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DMOH75D)

Drug Name

Para-chloroamphetamine Drug Info

Synonyms

p-CHLOROAMPHETAMINE; para-Chloroamphetamine; p-Chloramphetamine; 1-(4-chlorophenyl)propan-2-amine; 4-Chloramphetamine; 4-Chloroamphetamine; 64-12-0; Para Chloroamphetamine; DL-Chloramphetamine; (+-)-p-Chloramphetamine; C9H12ClN; (+-)-p-Chloroamphetamine; p-Chloroamphetamine (VAN); (+-)-4-Chloroamphetamine; NSC 287208; DL-p-Chloroamphetamine; LY-121860; alpha-Methyl-p-chlorophenethylamine; 4-Chloro-alpha-methylphenethylamine; Benzeneethanamine, 4-chloro-alpha-methyl-; (+-)-p-Chloro-alpha-methylphenethylamine; CHEMBL358967

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

PubChem CID: 3127
CAS Number: CAS 64-12-0
TTD Drug ID: DMOH75D

Molecule(s) Related to This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Dopamine transporter (DAT)	TTVBI8W	SC6A3_HUMAN	Inhibitor	[2]
Norepinephrine transporter (NET)	TTAWNKZ	SC6A2_HUMAN	Inhibitor	[2]
Serotonin transporter (SERT)	TT3ROYC	SC6A4_HUMAN	Inhibitor	[2]

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The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule	Molecule Type	Gene Name	Liver	Colon	Kidney	Small Intestine
Dopamine transporter (DAT)	DTT	SLC6A3	4	2.609	5.233	3.7
Norepinephrine transporter (NET)	DTT	SLC6A2	2.459	3.426	3.322	3.35
Serotonin transporter (SERT)	DTT	SLC6A4	6.278	5.469	6.075	6.966

Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease

Discovery agent

ICD Disease Classification

N.A.

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
Dopamine transporter (DAT)	DTT	SLC6A3	1.08E-03	-3.08	-1.99
Serotonin transporter (SERT)	DTT	SLC6A4	8.76E-01	7.18E-05	6.19E-04

Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1	URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 4592).
2	Synthesis and serotonin transporter activity of sulphur-substituted alpha-alkyl phenethylamines as a new class of anticancer agents. Eur J Med Chem. 2009 Dec;44(12):4862-88.