Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DMOZ1IY)

Drug Name

N2-[4-(benzyloxy)benzyl]glycinamide Drug Info

Synonyms

2-({[4-(benzyloxy)phenyl]methyl}amino)acetamide; CHEMBL348597; EN300-53966; 774506-05-7; N2-[4-(benzyloxy)benzyl]glycinamide; AC1Q4ZPD; SCHEMBL7391510; CTK7D3324; MolPort-004-292-381; ZINC21956233; BDBM50221278; AKOS000127788; MCULE-6620856689; NE46952; BBV-007676; 2-(4-Benzyloxy-benzylamino)-acetamide; 2-[[4-(Benzyloxy)benzyl]amino]acetamide

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

PubChem CID: 10588118
TTD Drug ID: DMOZ1IY

Molecule(s) Related to This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Monoamine oxidase type A (MAO-A)	TT3WG5C	AOFA_HUMAN	Inhibitor	[1]
Monoamine oxidase type B (MAO-B)	TTGP7BY	AOFB_HUMAN	Inhibitor	[1]

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The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule	Molecule Type	Gene Name	Liver	Colon	Kidney	Small Intestine
Monoamine oxidase type B (MAO-B)	DTT	MAOB	9.367	6.907	8.237	8.409
Monoamine oxidase type A (MAO-A)	DTT	MAOA	7.207	8.159	9.043	7.711

Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease

Discovery agent

ICD Disease Classification

N.A.

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
Monoamine oxidase type B (MAO-B)	DTT	MAOB	2.65E-02	1.12E-02	0.07
Monoamine oxidase type A (MAO-A)	DTT	MAOA	8.14E-01	0.05	0.1

Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1	Solid-phase synthesis and insights into structure-activity relationships of safinamide analogues as potent and selective inhibitors of type B monoa... J Med Chem. 2007 Oct 4;50(20):4909-16.