Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DMPH1RK)

Drug Name
Alferminogene tadenovec Drug Info
Synonyms Generx (TN)
Indication
Disease Entry ICD 11 Status REF
Angina pectoris BA40 Phase 3 [1]
Heart disease BA41-BA42 Phase 3 [2]
Cross-matching ID
TTD Drug ID
DMPH1RK

Molecule(s) Related to This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Fibroblast growth factor-4 (FGF4) TTCEKVZ FGF4_HUMAN Modulator [2]

The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule Molecule Type Gene Name Liver Colon Kidney Small Intestine
Fibroblast growth factor-4 (FGF4) DTT FGF4 7.239 6.847 6.564 7.131
Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease Angina pectoris
ICD Disease Classification BA40
Molecule Name Molecule Type Gene Name p-value Fold-Change Z-score
Fibroblast growth factor-4 (FGF4) DTT FGF4 1.74E-01 0.04 0.45
Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1 Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
2 Alferminogene tadenovec, an angiogenic FGF4 gene therapy for coronary artery disease. IDrugs. 2008 Apr;11(4):283-93.