Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DMQ0TBX)

Drug Name

4,4-Diphenylbutan-1-amine Drug Info

Synonyms

4,4-Diphenylbutylamine; 36765-74-9; EINECS 253-194-6; 4,4-Diphenylbutan-1-amine; diphenylbutylamine; AC1MI1YM; delta-Phenylbenzenebutanamine; Benzenebutanamine, d-phenyl-; SCHEMBL157808; diphenylalkylamine (DPA), 6a; CHEMBL593734; CTK4H7118; BDBM35935; DTXSID10190229; MAAQGZFMFXQVOG-UHFFFAOYSA-N; AKOS030583685

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

PubChem CID: 3015863
CAS Number: CAS 36765-74-9
TTD Drug ID: DMQ0TBX

Molecule(s) Related to This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
5-HT 2A receptor (HTR2A)	TTJQOD7	5HT2A_HUMAN	Inhibitor	[1]
Histamine H1 receptor (H1R)	TTTIBOJ	HRH1_HUMAN	Inhibitor	[1]

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The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule	Molecule Type	Gene Name	Liver	Colon	Kidney	Small Intestine
Histamine H1 receptor (H1R)	DTT	HRH1	5.972	5.7	5.816	6.002
5-HT 2A receptor (HTR2A)	DTT	HTR2A	4.84	4.904	4.652	4.129

Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease

Discovery agent

ICD Disease Classification

N.A.

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
Histamine H1 receptor (H1R)	DTT	HRH1	6.74E-01	0.13	0.43

Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1	Synthesis, structure-affinity relationships, and modeling of AMDA analogs at 5-HT2A and H1 receptors: structural factors contributing to selectivity. Bioorg Med Chem. 2009 Sep 15;17(18):6496-504.