Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DMQ3LMF)

Drug Name

Ethyl 4-(2-oxo-2H-chromene-3-carboxamido)benzoate Drug Info

Synonyms

111947-24-1; ethyl 4-{[(2-oxo-2H-chromen-3-yl)carbonyl]amino}benzoate; AC1LHTSN; CBMicro_028869; 3-carboxamido coumarin, 15; Oprea1_481544; ethyl 4-(2-oxo-2H-chromene-3-carboxamido)benzoate; CHEMBL470419; BDBM29165; MolPort-000-375-263; MISJYZJMFQOBPG-UHFFFAOYSA-N; ZINC434162; STK401564; AKOS001279407; MCULE-7936571021; LS-38062; BIM-0028988.P001; ST4083371; ethyl 4-(2-oxo-2H-chromene-3-amido)benzoate; ethyl 4-[(2-oxochromen-3-yl)carbonylamino]benzoate; ethyl 4-[(2-oxochromene-3-carbonyl)amino]benzoate; Z30248586; F1006-0090

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

PubChem CID: 869109
TTD Drug ID: DMQ3LMF

Molecule(s) Related to This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Monoamine oxidase type A (MAO-A)	TT3WG5C	AOFA_HUMAN	Inhibitor	[1]

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The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule	Molecule Type	Gene Name	Liver	Colon	Kidney	Small Intestine
Monoamine oxidase type A (MAO-A)	DTT	MAOA	7.207	8.159	9.043	7.711

Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease

Discovery agent

ICD Disease Classification

N.A.

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
Monoamine oxidase type A (MAO-A)	DTT	MAOA	8.14E-01	0.05	0.1

Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1	Synthesis, molecular modeling, and selective inhibitory activity against human monoamine oxidases of 3-carboxamido-7-substituted coumarins. J Med Chem. 2009 Apr 9;52(7):1935-42.