Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DMQCDT1)

Drug Name

7-Acetonyloxy-3,4-cyclohexene-8-methylcoumarin Drug Info

Synonyms

307550-03-4; CHEMBL488073; 4-METHYL-3-(2-OXOPROPOXY)-7,8,9,10-TETRAHYDRO-6H-BENZO[C]CHROMEN-6-ONE; CHEMBRDG-BB 6148717; AC1LDV7A; CBMicro_031517; 7-Acetonyloxy-3,4-cyclohexene-8-methylcoumarin; ZINC83523; CTK4G5861; DTXSID00351504; MolPort-000-688-897; ZX-CM016547; STL303255; BDBM50246265; AKOS002377920; MCULE-4345433569; AJ-10643; ACM307550034; BIM-0031568.P001; W-8890; SR-01000229174; SR-01000229174-1; 4-methyl-3-(2-oxopropoxy)-7,8,9,10-tetrahydrobenzo[c]chromen-6-one; 6H-Dibenzo[b,d]pyran-6-one, 7,8,9,10-tetrahydro-4-methyl-3-

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

PubChem CID: 701943
CAS Number: CAS 307550-03-4
TTD Drug ID: DMQCDT1

Molecule(s) Related to This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Monoamine oxidase type A (MAO-A)	TT3WG5C	AOFA_HUMAN	Inhibitor	[1]
Monoamine oxidase type B (MAO-B)	TTGP7BY	AOFB_HUMAN	Inhibitor	[1]

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The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule	Molecule Type	Gene Name	Liver	Colon	Kidney	Small Intestine
Monoamine oxidase type B (MAO-B)	DTT	MAOB	9.367	6.907	8.237	8.409
Monoamine oxidase type A (MAO-A)	DTT	MAOA	7.207	8.159	9.043	7.711

Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease

Discovery agent

ICD Disease Classification

N.A.

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
Monoamine oxidase type B (MAO-B)	DTT	MAOB	2.65E-02	1.12E-02	0.07
Monoamine oxidase type A (MAO-A)	DTT	MAOA	8.14E-01	0.05	0.1

Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1	Quantitative structure-activity relationship and complex network approach to monoamine oxidase A and B inhibitors. J Med Chem. 2008 Nov 13;51(21):6740-51.