Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DMQJXL4)

Drug Name
AMG 386 Drug Info
Synonyms
7440-23-5; Natrium; Sodium-23; Sodio; Sodium metal; Sodio [Spanish]; Sodium (liquid alloy); UNII-9NEZ333N27; HSDB 687; EINECS 231-132-9; UN1428; UNII-23J3BHR95O; Sodium, dry stick; 9NEZ333N27; MFCD00085307; Sodium, 998%, oiled sticks, wrapped in aluminium foil; monosodium; sodium atom; mono sodium; mono-sodium; Sodium, CP; SodiuR4733m hydride, CP; AC1NSENP; ACMC-1BKTZ; Sodium, ACS reagent, dry; 11Na; EC 231-132-9; AC1Q1W6R; SODIUM, LARGE PIECES; Sodium hydride, dry, 95%; NAH 80; HSDB 745; CTK2H7876; CHEBI:26708; Oravescent fentanyl; R3487; PT-15; R4930
Indication
Disease Entry ICD 11 Status REF
Breast cancer 2C60-2C65 Phase 3 [1] , [2]
Neuropathic pain 8E43.0 Phase 3 [3]
Alzheimer disease 8A20 Phase 2 [4]
Asthma CA23 Discontinued in Phase 2 [5]
Sexual dysfunction HA00-HA01 Preclinical [6]
Cross-matching ID
PubChem CID
5360545
ChEBI ID
CHEBI:26708
CAS Number
CAS 7440-23-5
TTD Drug ID
DMQJXL4

Molecule(s) Related to This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Angiopoietin-1 (ANGPT1) TTWNQ1T ANGP1_HUMAN Modulator [7]
Angiopoietin-2 (ANGPT2) TTKLQTJ ANGP2_HUMAN Modulator [7]
Gamma-secretase (GS) TT9W8GU APH1A_HUMAN; APH1B_HUMAN; PEN2_HUMAN; NICA_HUMAN; PSN1_HUMAN Inhibitor [8]
Melanocortin receptor 4 (MC4R) TTD0CIQ MC4R_HUMAN Agonist [6]
Neuronal acetylcholine receptor alpha-7 (CHRNA7) TTLA931 ACHA7_HUMAN Agonist [8]
Opioid receptor (OPR) TTN4QDT NOUNIPROTAC Agonist [3]
TAX transcriptionally-activated glycoprotein 1 (OX40) TTBW580 TNFL4_HUMAN Modulator [9]

The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule Molecule Type Gene Name Liver Colon Kidney Small Intestine
Angiopoietin-1 (ANGPT1) DTT ANGPT1 5.476 5.82 6.162 5.162
Angiopoietin-2 (ANGPT2) DTT ANGPT2 2.036 2.472 1.722 3.433
Melanocortin receptor 4 (MC4R) DTT MC4R 5.904 5.009 4.548 4.597
TAX transcriptionally-activated glycoprotein 1 (OX40) DTT TNFSF4 5.463 5.875 6 6.276
Gamma-secretase (GS) DTT APH1A; APH1B; NCSTN; PSENEN; PSEN1 7.23 7.775 7.538 7.928
Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease Breast cancer
ICD Disease Classification 2C60-2C65
Molecule Name Molecule Type Gene Name p-value Fold-Change Z-score
Gamma-secretase (GS) DTT APH1A; APH1B; NCSTN; PSENEN; PSEN1 1.47E-02 -0.09 -0.37
Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 8414).
2 ClinicalTrials.gov (NCT01281254) TRINOVA-2: Trebananib in Ovarian Cancer-2. U.S. National Institutes of Health.
3 Emerging drugs in neuropathic pain. Expert Opin Emerg Drugs. 2007 Mar;12(1):113-26.
4 Nicotinic receptors: allosteric transitions and therapeutic targets in the nervous system. Nat Rev Drug Discov. 2009 Sep;8(9):733-50.
5 Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800027884)
6 Emerging drugs for obesity: linking novel biological mechanisms to pharmaceutical pipelines. Expert Opin Emerg Drugs. 2005 Aug;10(3):643-60.
7 Interpreting expression profiles of cancers by genome-wide survey of breadth of expression in normal tissues. Genomics 2005 Aug;86(2):127-41.
8 Clinical pipeline report, company report or official report of Roche (2009).
9 Clinical targeting of the TNF and TNFR superfamilies.Nat Rev Drug Discov.2013 Feb;12(2):147-68.