Details of the Drug Therapeutic Target (DTT)

General Information of Drug Therapeutic Target (DTT) (ID: TTN4QDT)

• DTT Name: Opioid receptor (OPR)
• Synonyms: Opioid receptor
• Gene Name: NO-GeName
• DTT Type: Successful target; [1]
• Related Disease:
  Cough [ICD-11: MD12]
  Opioid use disorder [ICD-11: 6C43]
  Pain [ICD-11: MG30-MG3Z]
  Sensation disturbance [ICD-11: MB40]
  Substance abuse [ICD-11: 6C40]
• UniProt ID: NOUNIPROTAC
• TTD ID: T23547

Molecular Interaction Atlas (MIA) of This DTT

11 Approved Drug(s) Targeting This DTT

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Dextropropoxyphene	DM23HCX	Pain	MG30-MG3Z	Approved	[2]
Ketobemidone	DMM3L6Z	Pain	MG30-MG3Z	Approved	[3], [4]
Levorphanol	DMGS80V	Pain	MG30-MG3Z	Approved	[5]
Methadone	DMTW6IU	Dry cough	MD12	Approved	[1], [6]
Nalmefene	DM4YWCZ	Opioid dependence	6C43.2Z	Approved	[7], [8]
Naltrexone	DMUL45H	Alcohol dependence	6C40.2	Approved	[9], [4]
Oxymorphone	DM65AGJ	Pain	MG30-MG3Z	Approved	[10]
Pentazocine	DM1XBHS	Pain	MG30-MG3Z	Approved	[11], [12]
Sufentanil	DMU7YEL	Analgesia	MB40.8	Approved	[6]
Tilidine	DMJW0VS	Pain	MG30-MG3Z	Approved	[13], [4]
Dihydrocodeine	DMB0FWL	Cancer related pain	MG30	Phase 4	[14]

14 Clinical Trial Drug(s) Targeting This DTT

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
ALO-02	DMKLBHX	Pain	MG30-MG3Z	Phase 3	[15]
AMG 386	DMQJXL4	Breast cancer	2C60-2C65	Phase 3	[16]
Bupropion+Naltrexone	DMAR9ND	Obesity	5B81	Phase 3	[17]
AeroLEF	DMNO7BC	Pain	MG30-MG3Z	Phase 2	[18]
AZD-7268	DMC48SP	Anxiety disorder	6B00-6B0Z	Phase 2	[19]
CNSB-001	DM2PEU5	Neuropathic pain	8E43.0	Phase 2	[20]
JKB-122	DMARQ0H	Hepatitis virus infection	1E50-1E51	Phase 2	[21], [4]
NP-2	DMLMZ6Q	Influenza A virus infection	1E30	Phase 2	[22]
OCFENTANIL	DM8TDBY	Pain	MG30-MG3Z	Phase 2	[23], [4]
Odelepran	DMK0MJP	Alcohol dependence	6C40.2	Phase 2	[24]
Oxytrex	DMC3PJS	Pain	MG30-MG3Z	Phase 2	[25]
S-297995	DM26IH8	Opioid dependence	6C43.2Z	Phase 2	[26]
PTI-202	DMNO91Q	Pain	MG30-MG3Z	Phase 1	[27]
SYN-1001	DMX05W8	Pain	MG30-MG3Z	Phase 1	[28]

10 Discontinued Drug(s) Targeting This DTT

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Propiram fumarate	DMW9H7M	Cancer related pain	MG30	Discontinued in Phase 3	[29]
CereCRIB	DMG62H1	Pain	MG30-MG3Z	Discontinued in Phase 2	[30]
OxycoDex	DMHFOIX	Pain	MG30-MG3Z	Discontinued in Phase 2	[31]
PTI-701	DMGO2AV	Pain	MG30-MG3Z	Discontinued in Phase 2	[32]
Ultramorph	DMRDXYV	Pain	MG30-MG3Z	Discontinued in Phase 2	[33]
BL-1827	DMJWLBU	Cancer related pain	MG30	Discontinued in Phase 1	[34]
APF-580	DMYD04O	Pain	MG30-MG3Z	Terminated	[36]
EK-399	DMIP8NB	Inflammation	1A00-CA43.1	Terminated	[37]
Org-30035	DMMA92L	Psychotic disorder	6A20-6A25	Terminated	[38]
OX-23	DMESWV1	Pain	MG30-MG3Z	Terminated	[39]

1 Preclinical Drug(s) Targeting This DTT

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
CB-01-16	DMKFAG3	Constipation	DD91.1	Preclinical	[35]

2 Investigative Drug(s) Targeting This DTT

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
BRIFENTANIL	DM2JPX7	Pain	MG30-MG3Z	Investigative	[40], [4]
Cyprodine	DM7T96M	Parkinson disease	8A00.0	Investigative	[41]

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