Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DMQK4I2)

Drug Name

(S)-4C3HPG Drug Info

Synonyms

(S)-4-CARBOXY-3-HYDROXYPHENYLGLYCINE; 85148-82-9; (s)-4C3HPG; DFS3SIU1ME; UNII-DFS3SIU1ME; (S)-4-(amino(carboxy)methyl)-2-hydroxybenzoic acid; CHEMBL39372; (S)-4C3H-PG; Benzeneacetic acid, alpha-amino-4-carboxy-3-hydroxy-, (alphaS)-; 4-[(1S)-1-amino-2-hydroxy-2-oxoethyl]-2-hydroxybenzoic acid; 4C3HPG; Tocris-0320; 4-Carboxy-3-hydroxyphenylglycine, (S)-; AC1NSKO9; GTPL1374; SCHEMBL12648356; CTK8F2145; MolPort-003-983-491; ZINC2559031; PDSP1_001316; PDSP2_001300; BDBM50053585; 4-Carboxy-3-hydroxy-L-phenylglycine; BN0022

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

PubChem CID: 5311455
CAS Number: CAS 85148-82-9
TTD Drug ID: DMQK4I2

Molecule(s) Related to This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Metabotropic glutamate receptor 1 (mGluR1)	TTVBPDM	GRM1_HUMAN	Antagonist	[2]
Metabotropic glutamate receptor 2 (mGluR2)	TTXJ47W	GRM2_HUMAN	Agonist	[3]
Metabotropic glutamate receptor 5 (mGluR5)	TTHS256	GRM5_HUMAN	Antagonist	[2]

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The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule	Molecule Type	Gene Name	Liver	Colon	Kidney	Small Intestine
Metabotropic glutamate receptor 2 (mGluR2)	DTT	GRM2	3.621	3.472	3.053	4.225
Metabotropic glutamate receptor 1 (mGluR1)	DTT	GRM1	3.888	3.848	3.711	3.678
Metabotropic glutamate receptor 5 (mGluR5)	DTT	GRM5	3.621	1.888	3.567	4.318

Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease

Discovery agent

ICD Disease Classification

N.A.

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
Metabotropic glutamate receptor 5 (mGluR5)	DTT	GRM5	9.81E-07	-0.26	-0.54

Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1	URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 1374).
2	Characterization of [(3)H]Quisqualate binding to recombinant rat metabotropic glutamate 1a and 5a receptors and to rat and human brain sections. J Neurochem. 2000 Dec;75(6):2590-601.
3	Characterization of [3H]-(2S,2'R,3'R)-2-(2',3'-dicarboxy-cyclopropyl)glycine ([3H]-DCG IV) binding to metabotropic mGlu2 receptor-transfected cell membranes. Br J Pharmacol. 1998 Feb;123(3):497-504.