Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DMQNXL1)

Drug Name

4,8-Dimethyl-7-(2'-oxocyclohexyloxy)coumarin Drug Info

Synonyms

CHEMBL488917; 4,8-dimethyl-7-((2-oxocyclohexyl)oxy)-2H-chromen-2-one; 4,8-dimethyl-7-[(2-oxocyclohexyl)oxy]-2H-chromen-2-one; AC1N8LB1; MLS001213498; MolPort-000-837-574; HMS2863H04; STL528052; BDBM50246220; AKOS030497124; MCULE-3956285825; SMR000540525; 4,8-Dimethyl-7-(2''-oxocyclohexyloxy)coumarin; 4,8-dimethyl-7-(2-oxocyclohexyl)oxychromen-2-one

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

PubChem CID: 4297278
TTD Drug ID: DMQNXL1

Molecule(s) Related to This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Monoamine oxidase type A (MAO-A)	TT3WG5C	AOFA_HUMAN	Inhibitor	[1]
Monoamine oxidase type B (MAO-B)	TTGP7BY	AOFB_HUMAN	Inhibitor	[1]

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The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule	Molecule Type	Gene Name	Liver	Colon	Kidney	Small Intestine
Monoamine oxidase type B (MAO-B)	DTT	MAOB	9.367	6.907	8.237	8.409
Monoamine oxidase type A (MAO-A)	DTT	MAOA	7.207	8.159	9.043	7.711

Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease

Discovery agent

ICD Disease Classification

N.A.

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
Monoamine oxidase type B (MAO-B)	DTT	MAOB	2.65E-02	1.12E-02	0.07
Monoamine oxidase type A (MAO-A)	DTT	MAOA	8.14E-01	0.05	0.1

Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1	Quantitative structure-activity relationship and complex network approach to monoamine oxidase A and B inhibitors. J Med Chem. 2008 Nov 13;51(21):6740-51.