Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DMQTREB)

Drug Name
Uridine Drug Info
Synonyms
uridine; 58-96-8; Uridin; Uracil riboside; beta-Uridine; d-uridine; CHEBI:16704; b-Uridine; UNII-WHI7HQ7H85; Urd; AI3-52690; EINECS 200-407-5; WHI7HQ7H85; MLS000069625; Uracil-1-beta-d-ribofuranoside; C9H12N2O6; DRTQHJPVMGBUCF-XVFCMESISA-N; SMR000058222; 1-((2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)pyrimidine-2,4(1H,3H)-dione; 1-beta-D-ribofuranosylpyrimidine-2,4(1H,3H)-dione
Indication
Disease Entry ICD 11 Status REF
Depression 6A70-6A7Z Approved [1]
Cross-matching ID
PubChem CID
6029
ChEBI ID
CHEBI:16704
CAS Number
CAS 58-96-8
TTD Drug ID
DMQTREB
VARIDT Drug ID
DR00321
INTEDE Drug ID
DR2135

Molecule(s) Related to This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Thymidine phosphorylase (TYMP) TTO0IB8 TYPH_HUMAN Inhibitor [2]

Drug Transporter (DTP)
DTP Name DTP ID UniProt ID Highest Status REF
Concentrative nucleoside transporter 1 (SLC28A1) DT0EQPW S28A1_HUMAN Approved [3]
Concentrative nucleoside transporter 2 (SLC28A2) DT82KPY S28A2_HUMAN Approved [4]

Drug-Metabolizing Enzyme (DME)
DME Name DME ID UniProt ID Highest Status REF
Uridine-cytidine kinase 1 (UCK1) DE478BP UCK1_HUMAN Approved [5]
Nicotinamide riboside kinase 1 (NRK1) DENV24I NRK1_HUMAN Approved [6]
Nicotinamide riboside kinase 2 (NRK2) DE8DJ3N NRK2_HUMAN Approved [6]
Uridine-cytidine kinase 2 (UCK2) DETN1O0 UCK2_HUMAN Approved [5]

The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule Molecule Type Gene Name Liver Colon Kidney Small Intestine
Thymidine phosphorylase (TYMP) DTT TYMP 6.621 5.534 6.051 6.682
Concentrative nucleoside transporter 2 (SLC28A2) DTP CNT2 5.318 5.135 5.269 8.681
Concentrative nucleoside transporter 1 (SLC28A1) DTP CNT1 6.939 4.771 5.736 6.651
Nicotinamide riboside kinase 1 (NRK1) DME NMRK1 6.945 6.707 7.184 7.592
Nicotinamide riboside kinase 2 (NRK2) DME NMRK2 5.252 5.615 4.036 3.991
Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease Depression
ICD Disease Classification 6A70-6A7Z
Molecule Name Molecule Type Gene Name p-value Fold-Change Z-score
Thymidine phosphorylase (TYMP) DTT TYMP 6.50E-01 -0.03 -0.25
Concentrative nucleoside transporter 2 (SLC28A2) DTP CNT2 1.04E-01 -4.21E-02 -3.44E-01
Concentrative nucleoside transporter 1 (SLC28A1) DTP CNT1 3.82E-01 3.88E-02 2.66E-01
Nicotinamide riboside kinase 1 (NRK1) DME NMRK1 5.11E-01 1.57E-02 4.25E-02
Nicotinamide riboside kinase 2 (NRK2) DME NMRK2 5.46E-01 -4.62E-02 -2.57E-01
Uridine-cytidine kinase 1 (UCK1) DME UCK1 4.70E-01 -3.84E-02 -2.47E-01
Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 4566).
2 Enzymatic activities of uridine and thymidine phosphorylase in normal and cancerous uterine cervical tissues. Hum Cell. 2007 Nov;20(4):107-10.
3 Electrophysiological recordings of CNT1 (SLC28A1) activity on Nanions SURFE2R N1.
4 Transport of ribavirin across the rat and human placental barrier: Roles of nucleoside and ATP-binding cassette drug efflux transporters. Biochem Pharmacol. 2019 May;163:60-70.
5 Phosphorylation of uridine and cytidine nucleoside analogs by two human uridine-cytidine kinases. Mol Pharmacol. 2001 May;59(5):1181-6.
6 Nicotinamide riboside kinase structures reveal new pathways to NAD+. PLoS Biol. 2007 Oct 2;5(10):e263.