Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DMRK4IE)

Drug Name
Aryl piperazine derivative 15 Drug Info
Synonyms PMID30124346-Compound-33TABLE3
Cross-matching ID
PubChem CID
118190855
TTD Drug ID
DMRK4IE

Molecule(s) Related to This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
5-HT 1 receptor (5HT1R) TTWT5K7 NOUNIPROTAC Agonist [1]
5-HT 1A receptor (HTR1A) TTSQIFT 5HT1A_HUMAN Agonist [1]

The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule Molecule Type Gene Name Liver Colon Kidney Small Intestine
5-HT 1A receptor (HTR1A) DTT HTR1A 4.661 5.289 3.053 3.472
Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

Molecule Name Molecule Type Gene Name p-value Fold-Change Z-score
5-HT 1A receptor (HTR1A) DTT HTR1A 7.49E-01 -0.02 -0.06
5-HT 1A receptor (HTR1A) DTT HTR1A 3.45E-01 -0.02 -0.14
Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1 5-HT1A receptor ligands and their therapeutic applications: review of new patents.Expert Opin Ther Pat. 2018 Sep;28(9):679-689.