Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DMRM1QV)

• Drug Name: Tenocyclidine Drug Info
• Synonyms: TENOCYCLIDINE; thienyl cyclohexylpiperidine; Tenocyclidinum; Tenociclidina; 1-(1-(2-Thienyl)cyclohexyl)piperidine; Tenocyclidine [INN]; 21500-98-1; UNII-8BQ45Q6VCL; Tenocyclidinum [INN-Latin]; 1-[1-(2-thienyl)cyclohexyl]piperidine; 8BQ45Q6VCL; Tenociclidina [INN-Spanish]; CHEMBL279676; Piperidine, 1-(1-(2-thienyl)cyclohexyl)-; DEA No. 7470; Thiophene analog of phencyclidine; CHEBI:64610; 2-Thienyl analog of phencyclidine; JUZZEWSCNBCFRL-UHFFFAOYSA-N; BRN 1246605; 1-(1-[2-Thienyl]cyclohexyl)piperidine; NCGC00160467-01

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

• Cross-matching ID:
  PubChem CID: 62751
  ChEBI ID: CHEBI:64610
  CAS Number: CAS 21500-98-1
  TTD Drug ID: DMRM1QV

Molecule(s) Related to This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Glutamate receptor ionotropic NMDA 2A (NMDAR2A)	TTKJEMQ	NMDE1_HUMAN	Antagonist	[1]
Glutamate receptor ionotropic NMDA 2B (NMDAR2B)	TTN9D8E	NMDE2_HUMAN	Antagonist	[1]

The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule	Molecule Type	Gene Name	Liver	Colon	Kidney	Small Intestine
Glutamate receptor ionotropic NMDA 2B (NMDAR2B)	DTT	GRIN2B	4.926	3.921	4.542	5.682
Glutamate receptor ionotropic NMDA 2A (NMDAR2A)	DTT	GRIN2A	5	5.446	5.459	3.35

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

• The Studied Disease: Discovery agent
• ICD Disease Classification: N.A.

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
Glutamate receptor ionotropic NMDA 2B (NMDAR2B)	DTT	GRIN2B	7.51E-01	-0.06	-0.32
Glutamate receptor ionotropic NMDA 2A (NMDAR2A)	DTT	GRIN2A	8.43E-01	-0.37	-0.45

References

• [1] The binding of [3H]thienyl cyclohexylpiperidine ([3H]TCP) to the NMDA-phencyclidine receptor complex. Neuropharmacology. 1989 Jan;28(1):1-7.