Details of the Drug

General Information of Drug (ID: DMRM1QV)

Drug Name

Tenocyclidine

Synonyms

TENOCYCLIDINE; thienyl cyclohexylpiperidine; Tenocyclidinum; Tenociclidina; 1-(1-(2-Thienyl)cyclohexyl)piperidine; Tenocyclidine [INN]; 21500-98-1; UNII-8BQ45Q6VCL; Tenocyclidinum [INN-Latin]; 1-[1-(2-thienyl)cyclohexyl]piperidine; 8BQ45Q6VCL; Tenociclidina [INN-Spanish]; CHEMBL279676; Piperidine, 1-(1-(2-thienyl)cyclohexyl)-; DEA No. 7470; Thiophene analog of phencyclidine; CHEBI:64610; 2-Thienyl analog of phencyclidine; JUZZEWSCNBCFRL-UHFFFAOYSA-N; BRN 1246605; 1-(1-[2-Thienyl]cyclohexyl)piperidine; NCGC00160467-01

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]
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Drug Type

Small molecular drug

Structure

3D MOL

2D MOL

#Ro5 Violations (Lipinski): 0

Molecular Weight (mw)

249.4

Logarithm of the Partition Coefficient (xlogp)

3.9

Rotatable Bond Count (rotbonds)

2

Hydrogen Bond Donor Count (hbonddonor)

0

Hydrogen Bond Acceptor Count (hbondacc)

2

Chemical Identifiers

Formula: C15H23NS
IUPAC Name: 1-(1-thiophen-2-ylcyclohexyl)piperidine
Canonical SMILES: C1CCC(CC1)(C2=CC=CS2)N3CCCCC3
InChI: InChI=1S/C15H23NS/c1-3-9-15(10-4-1,14-8-7-13-17-14)16-11-5-2-6-12-16/h7-8,13H,1-6,9-12H2
InChIKey: JUZZEWSCNBCFRL-UHFFFAOYSA-N

Cross-matching ID

PubChem CID: 62751
ChEBI ID: CHEBI:64610
CAS Number: 21500-98-1
DrugBank ID: DB01520
TTD ID: D00VKV

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Glutamate receptor ionotropic NMDA 2A (NMDAR2A)	TTKJEMQ	NMDE1_HUMAN	Antagonist	[1]
Glutamate receptor ionotropic NMDA 2B (NMDAR2B)	TTN9D8E	NMDE2_HUMAN	Antagonist	[1]

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Molecular Interaction Atlas (MIA)

MIA Detail

Jump to Detail Molecular Interaction Atlas of This Drug

Molecular Expression Atlas of This Drug

The Studied Disease

Discovery agent

ICD Disease Classification

N.A.

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
Glutamate receptor ionotropic NMDA 2B (NMDAR2B)	DTT	GRIN2B	7.51E-01	-0.06	-0.32
Glutamate receptor ionotropic NMDA 2A (NMDAR2A)	DTT	GRIN2A	8.43E-01	-0.37	-0.45

Molecular Expression Atlas (MEA)

MEA Detail

Jump to Detail Molecular Expression Atlas of This Drug

References

1	The binding of [3H]thienyl cyclohexylpiperidine ([3H]TCP) to the NMDA-phencyclidine receptor complex. Neuropharmacology. 1989 Jan;28(1):1-7.