Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DMSME2B)

Drug Name	PMID29130358-Compound-Figure11(3) Drug Info
Cross-matching ID	TTD Drug ID DMSME2B

Molecule(s) Related to This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Matrix metalloproteinase-2 (MMP-2)	TTLM12X	MMP2_HUMAN	Inhibitor	[1]
Tyrosinase (TYR)	TTULVH8	TYRO_HUMAN	Inhibitor	[1]

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The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule	Molecule Type	Gene Name	Liver	Colon	Kidney	Small Intestine
Tyrosinase (TYR)	DTT	TYR	5.959	5.711	5.973	4.912
Matrix metalloproteinase-2 (MMP-2)	DTT	MMP2	5.766	9.299	8.247	8.608

Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
Tyrosinase (TYR)	DTT	TYR	5.99E-01	-0.14	-0.76
Matrix metalloproteinase-2 (MMP-2)	DTT	MMP2	1.29E-01	0.25	0.83

Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1	Gelatinase inhibitors: a patent review (2011-2017).Expert Opin Ther Pat. 2018 Jan;28(1):31-46.