Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DMSVCJM)

Drug Name

5-Bromo-8-piperazin-1-yl-imidazo[1,2-a]pyrazine Drug Info

Synonyms

CHEMBL123566; 5-Bromo-8-piperazin-1-yl-imidazo[1,2-a]pyrazine; BDBM50002150; 143591-65-5; 5-Bromo-8-(1-piperazinyl)imidazo[1,2-a]pyrazine; Imidazo[1,2-a]pyrazine, 5-bromo-8-(1-piperazinyl)-

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

PubChem CID: 10379016
TTD Drug ID: DMSVCJM

Molecule(s) Related to This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Adrenergic receptor alpha-1A (ADRA1A)	TTNGILX	ADA1A_HUMAN	Inhibitor	[1]
Adrenergic receptor alpha-1D (ADRA1D)	TT34BHT	ADA1D_HUMAN	Inhibitor	[1]

------------------------------------------------------------------------------------

The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule	Molecule Type	Gene Name	Liver	Colon	Kidney	Small Intestine
Adrenergic receptor alpha-1A (ADRA1A)	DTT	ADRA1A	3.154	3.853	4.129	2.963

Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease

Discovery agent

ICD Disease Classification

N.A.

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
Adrenergic receptor alpha-1A (ADRA1A)	DTT	ADRA1A	9.43E-01	-0.03	-0.25

Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1	Synthesis and hypoglycemic activity of substituted 8-(1-piperazinyl)imidazo[1,2-a]pyrazines. J Med Chem. 1992 Oct 16;35(21):3845-57.