Details of the Drug

General Information of Drug (ID: DMSVCJM)

• Drug Name: 5-Bromo-8-piperazin-1-yl-imidazo[1,2-a]pyrazine
• Synonyms: CHEMBL123566; 5-Bromo-8-piperazin-1-yl-imidazo[1,2-a]pyrazine; BDBM50002150; 143591-65-5; 5-Bromo-8-(1-piperazinyl)imidazo[1,2-a]pyrazine; Imidazo[1,2-a]pyrazine, 5-bromo-8-(1-piperazinyl)-

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

• Drug Type: Small molecular drug
• #Ro5 Violations (Lipinski): 0:
  Molecular Weight (mw); 282.14
  Logarithm of the Partition Coefficient (xlogp); 1.5
  Rotatable Bond Count (rotbonds); 1
  Hydrogen Bond Donor Count (hbonddonor); 1
  Hydrogen Bond Acceptor Count (hbondacc); 4
• Chemical Identifiers:
  Formula: C10H12BrN5
  IUPAC Name: 5-bromo-8-piperazin-1-ylimidazo[1,2-a]pyrazine
  Canonical SMILES: C1CN(CCN1)C2=NC=C(N3C2=NC=C3)Br
  InChI: InChI=1S/C10H12BrN5/c11-8-7-14-9(10-13-3-6-16(8)10)15-4-1-12-2-5-15/h3,6-7,12H,1-2,4-5H2
  InChIKey: SOIWQJOBNCOQPP-UHFFFAOYSA-N
• Cross-matching ID:
  PubChem CID: 10379016
  TTD ID: D0R2YM

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Adrenergic receptor alpha-1A (ADRA1A)	TTNGILX	ADA1A_HUMAN	Inhibitor	[1]
Adrenergic receptor alpha-1D (ADRA1D)	TT34BHT	ADA1D_HUMAN	Inhibitor	[1]

Molecular Expression Atlas of This Drug

• The Studied Disease: Discovery agent
• ICD Disease Classification: N.A.

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
Adrenergic receptor alpha-1A (ADRA1A)	DTT	ADRA1A	9.43E-01	-0.03	-0.25

References

• [1] Synthesis and hypoglycemic activity of substituted 8-(1-piperazinyl)imidazo[1,2-a]pyrazines. J Med Chem. 1992 Oct 16;35(21):3845-57.