Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DMT0KB1)

Drug Name

PSD-506 Drug Info

Synonyms

Muscarinic M2 antagonists, Roche; Ro-320-2904; M2/M3 muscarinic antagonists (benign prostate hyperplasia), Roche/Plethora; M2/M3 muscarinic antagonists (overactive bladder), Roche/Plethora; M2/M3 muscarinic antagonists (urge incontinence), Roche/Plethora; M2/M3 muscarinic antagonists (urological disorders), Roche/Plethora

Indication

Disease Entry	ICD 11	Status	REF
Overactive bladder	GC50.0	Discontinued in Phase 2	[1]

Cross-matching ID

PubChem CID: 10273877
TTD Drug ID: DMT0KB1

Molecule(s) Related to This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Muscarinic acetylcholine receptor M2 (CHRM2)	TTYEG6Q	ACM2_HUMAN	Modulator	[2]
Muscarinic acetylcholine receptor M3 (CHRM3)	TTQ13Z5	ACM3_HUMAN	Modulator	[2]

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The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease

Overactive bladder

ICD Disease Classification

GC50.0

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
Muscarinic acetylcholine receptor M2 (CHRM2)	DTT	CHRM2	4.61E-07	-0.59	-0.73
Muscarinic acetylcholine receptor M3 (CHRM3)	DTT	CHRM3	4.61E-07	-0.59	-0.73

Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1	Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800022973)
2	Interpreting expression profiles of cancers by genome-wide survey of breadth of expression in normal tissues. Genomics 2005 Aug;86(2):127-41.