Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DMT3D5I)

Drug Name
Aflibercept Drug Info
Synonyms Ziv-Aflibercept; Zaltrap (TN); VEGF Trap; VEGF Trap-Eye
Indication
Disease Entry ICD 11 Status REF
Central retinal vein occlusion with macular edema Approved [1]
Diabetic macular edema 9B71.02 Approved [2]
Exudative age-related macular degeneration 9B78.3Z Approved [3]
Metastasis from malignant tumor of colon Approved [4]
Metastatic colorectal cancer 2B91 Approved [5]
Cross-matching ID
TTD Drug ID
DMT3D5I

Molecule(s) Related to This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Placenta growth factor (PlGF) TT48I1Y PLGF_HUMAN Modulator [5]
Vascular endothelial growth factor A (VEGFA) TTOHSBA VEGFA_HUMAN Modulator [5]
Vascular endothelial growth factor B (VEGFB) TTPJQHE VEGFB_HUMAN Modulator [5]

The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule Molecule Type Gene Name Liver Colon Kidney Small Intestine
Vascular endothelial growth factor B (VEGFB) DTT VEGFB 6.333 6.18 5.812 5.739
Vascular endothelial growth factor A (VEGFA) DTT VEGFA 8.544 6.927 7.253 7.839
Placenta growth factor (PlGF) DTT PGF 6.163 7.095 7.039 7.016
Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease Central retinal vein occlusion with macular edema
ICD Disease Classification
Molecule Name Molecule Type Gene Name p-value Fold-Change Z-score
Vascular endothelial growth factor A (VEGFA) DTT VEGFA 3.61E-01 0.15 0.47
Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1 A review of neovascular glaucoma. Etiopathogenesis and treatment. Rom J Ophthalmol. 2021 Oct-Dec;65(4):315-329.
2 Aflibercept versus Faricimab in the Treatment of Neovascular Age-Related Macular Degeneration and Diabetic Macular Edema: A Review. Int J Mol Sci. 2022 Aug 20;23(16):9424.
3 Efficacy and Safety of Intravitreal Aflibercept Treat-and-Extend Regimens in Exudative Age-Related Macular Degeneration: 52- and 96-Week Findings from ALTAIR : A Randomized Controlled Trial. Adv Ther. 2020 Mar;37(3):1173-1187.
4 A Comparison of Folinic Acid, Fluorouracil and Irinotecan (FOLFIRI) plus Bevacizumab and FOLFIRI plus Aflibercept as Second-line Treatment for Metastatic Colorectal Cancer. Clin Oncol (R Coll Radiol). 2022 Aug;34(8):e323-e328.
5 Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015