Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DMT81N3)

• Drug Name: 1-(4-(benzyloxy)phenyl)propan-2-amine Drug Info
• Synonyms: 4-Benzyloxyamphetamine; 1-(4-phenylmethoxyphenyl)propan-2-amine; CHEMBL456013; 7176-39-8; ZDZASCUBDMUTSR-UHFFFAOYSA-N; p-benzyloxyamphetamine; 1-(4-(benzyloxy)phenyl)propan-2-amine; Phenethylamine, p-(benzyloxy)-alpha-methyl-; alpha-Methyl-4-(phenylmethoxy)benzeneethanamine; AC1L34WV; Benzeneethanamine, alpha-methyl-4-(phenylmethoxy)-; SCHEMBL2750286; AC1Q56Y9; CTK2H7369; BDBM50276775; AKOS022489255; AKOS000152896; 1-(4-phenylmethoxyphenyl)-2-propanamine; 1-Methyl-2-(4-benzyloxyphenyl)ethanamine

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

• Cross-matching ID:
  PubChem CID: 134616
  CAS Number: CAS 7176-39-8
  TTD Drug ID: DMT81N3

Molecule(s) Related to This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Monoamine oxidase type A (MAO-A)	TT3WG5C	AOFA_HUMAN	Inhibitor	[1]
Monoamine oxidase type B (MAO-B)	TTGP7BY	AOFB_HUMAN	Inhibitor	[1]

The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule	Molecule Type	Gene Name	Liver	Colon	Kidney	Small Intestine
Monoamine oxidase type B (MAO-B)	DTT	MAOB	9.367	6.907	8.237	8.409
Monoamine oxidase type A (MAO-A)	DTT	MAOA	7.207	8.159	9.043	7.711

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

• The Studied Disease: Discovery agent
• ICD Disease Classification: N.A.

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
Monoamine oxidase type B (MAO-B)	DTT	MAOB	2.65E-02	1.12E-02	0.07
Monoamine oxidase type A (MAO-A)	DTT	MAOA	8.14E-01	0.05	0.1

References

• [1] Naphthylisopropylamine and N-benzylamphetamine derivatives as monoamine oxidase inhibitors. Bioorg Med Chem. 2009 Mar 15;17(6):2452-60.