Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DMTPFLU)

Drug Name

Quinoline-8-sulfonamide Drug Info

Synonyms

quinoline-8-sulfonamide; 8-Quinolinesulfonamide; 35203-91-9; 8-Sulfonamidoquinoline; Quinoline-8-sulfonic acid amide; CCRIS 7819; CHEMBL268809; SMR000009729; 8-quinoline-sulfonamide; 8-(Sulfamoyl)quinoline; AC1Q6ULO; AC1L3S9X; SCHEMBL50688; Oprea1_399346; Oprea1_819599; MLS001075858; MLS000070229; MLS001075623; CTK1C3889; DTXSID30188709; MolPort-000-398-364; ZTYZEUXZHGOXRT-UHFFFAOYSA-N; ZINC275697; HMS2220E20; HMS3356M20; ALBB-006579; NSC67458; STK387517; NSC-67458; 1294AE; BDBM50125190; AKOS000678636; MCULE-8159242011; BAS 00926056

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

PubChem CID: 94464
CAS Number: CAS 35203-91-9
TTD Drug ID: DMTPFLU

Molecule(s) Related to This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Carbonic anhydrase II (CA-II)	TTANPDJ	CAH2_HUMAN	Inhibitor	[1]
Carbonic anhydrase IX (CA-IX)	TT2LVK8	CAH9_HUMAN	Inhibitor	[1]

------------------------------------------------------------------------------------

The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule	Molecule Type	Gene Name	Liver	Colon	Kidney	Small Intestine
Carbonic anhydrase II (CA-II)	DTT	CA2	8.796	10.933	9.395	9.819
Carbonic anhydrase IX (CA-IX)	DTT	CA9	5.04	6.156	4.609	6.756

Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease

Discovery agent

ICD Disease Classification

N.A.

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
Carbonic anhydrase II (CA-II)	DTT	CA2	7.95E-08	0.52	0.33
Carbonic anhydrase IX (CA-IX)	DTT	CA9	1.12E-10	-0.03	-0.09

Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1	Ligand-based and structure-based virtual screening to identify carbonic anhydrase IX inhibitors. Bioorg Med Chem. 2009 Jan 15;17(2):553-7.