Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DMTR7EH)

Drug Name
Desoxypeganine Drug Info
Synonyms Alcoholism therapy, HF Arzneimittelforschung; Desoxypeganine, HF Arzneimittelforschung
Indication
Disease Entry ICD 11 Status REF
Alcohol dependence 6C40.2 Phase 1 [1]
Cross-matching ID
PubChem CID
442894
ChEBI ID
CHEBI:4428
CAS Number
CAS 495-59-0
TTD Drug ID
DMTR7EH

Molecule(s) Related to This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Acetylcholinesterase (AChE) TT1RS9F ACES_HUMAN Modulator [1]
Monoamine oxidase type A (MAO-A) TT3WG5C AOFA_HUMAN Modulator [1]

The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule Molecule Type Gene Name Liver Colon Kidney Small Intestine
Monoamine oxidase type A (MAO-A) DTT MAOA 7.207 8.159 9.043 7.711
Acetylcholinesterase (AChE) DTT ACHE 1.678 1.926 1.766 5.252
Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease Alcohol dependence
ICD Disease Classification 6C40.2
Molecule Name Molecule Type Gene Name p-value Fold-Change Z-score
Monoamine oxidase type A (MAO-A) DTT MAOA 6.93E-01 -0.36 -0.41
Acetylcholinesterase (AChE) DTT ACHE 6.39E-02 -1.07 -1.15
Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1 Phase I clinical trial with desoxypeganine, a new cholinesterase and selective MAO-A inhibitor: tolerance and pharmacokinetics study of escalating single oral doses. Methods Find Exp Clin Pharmacol. 2008 Mar;30(2):141-7.