Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DMU04ZQ)

Drug Name

1-naphthalen-2-yl-2-pyrrolidin-1-yl-pentan-1-one Drug Info

Synonyms

naphyrone; 1-(Naphthalen-2-yl)-2-(pyrrolidin-1-yl)pentan-1-one; 850352-11-3; 850352-53-3; Naphyrone (O-2482); CHEMBL204759; naphthylpyrovalerone; beta-Naphyrone; O-2482; 1-naphthalen-2-yl-2-pyrrolidin-1-yl-pentan-1-one; SCHEMBL4939526; DEA No. 1258; CTK8C0838; ACT06821; BDBM50182546; ANW-65341; AKOS015898953; KB-215797; AX8234386; AB1004335; TC-154086; I14-12001; 1-Pentanone, 1-(2-naphthalenyl)-2-(1-pyrrolidinyl)-; 850352-53-3,850352-11-3(HCl); 1-(1-(naphthalen-2-yl)-1-oxopentan-2-yl)pyrrolidinium chloride

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

PubChem CID: 11243002
CAS Number: CAS 850352-53-3
TTD Drug ID: DMU04ZQ

Molecule(s) Related to This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Dopamine transporter (DAT)	TTVBI8W	SC6A3_HUMAN	Inhibitor	[1]
Norepinephrine transporter (NET)	TTAWNKZ	SC6A2_HUMAN	Inhibitor	[1]
Serotonin transporter (SERT)	TT3ROYC	SC6A4_HUMAN	Inhibitor	[1]

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The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule	Molecule Type	Gene Name	Liver	Colon	Kidney	Small Intestine
Dopamine transporter (DAT)	DTT	SLC6A3	4	2.609	5.233	3.7
Norepinephrine transporter (NET)	DTT	SLC6A2	2.459	3.426	3.322	3.35
Serotonin transporter (SERT)	DTT	SLC6A4	6.278	5.469	6.075	6.966

Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease

Discovery agent

ICD Disease Classification

N.A.

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
Dopamine transporter (DAT)	DTT	SLC6A3	1.08E-03	-3.08	-1.99
Serotonin transporter (SERT)	DTT	SLC6A4	8.76E-01	7.18E-05	6.19E-04

Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1	1-(4-Methylphenyl)-2-pyrrolidin-1-yl-pentan-1-one (Pyrovalerone) analogues: a promising class of monoamine uptake inhibitors. J Med Chem. 2006 Feb 23;49(4):1420-32.