Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DMU8JGH)

Drug Name

Hydralazine Drug Info

Synonyms

Apresolin; Apresoline; Apressin; Apressoline; Aprezolin; HLZ; Hidral; Hidralazin; Hidralazina; Hipoftalin; Hydralazin; Hydralazinum; Hydrallazin; Hydrallazine; Hydrazinophthalazine; Hypophthalin; Idralazina; Hidralazina [Spanish]; Idralazina [DCIT]; Idralazina [Italian]; BA 5968; C 5968; Ciba 5968; Praparat 5968; Apresoline (TN); Apressin (pharmaceutical); C-5068; C-5968; Hidral (TN); Hidralazina [INN-Spanish]; Hydralazine (INN); Hydralazine [INN:BAN]; Hydralazinum [INN-Latin]; Hydrazone 1(2H)-phthalazinone; Phthalazin-1-ylhydrazine; [2H-Phthalazin-(1Z)-Ylidene]-Hydrazine Hydrochloride; (1Z)-1(2H)-Phthalazinone hydrazone; (2H)-Phthalazinone hydrazone; 1(2H)-Phthalazinone hydrazone; 1(2H)-Phthalazinone, hydrazone; 1-Hydrazinophthalazine; 1-Phthalazinylhydrazine; 6-Hydralazine

Indication

Disease Entry	ICD 11	Status	REF
Chronic heart failure	BD1Z	Approved	[1]
Hypertension	BA00-BA04	Approved	[2]
Malignant essential hypertension	BA00	Approved	[1]

Therapeutic Class

Antihypertensive Agents

Cross-matching ID

PubChem CID: 3637
ChEBI ID: CHEBI:5775
CAS Number: CAS 86-54-4
TTD Drug ID: DMU8JGH
VARIDT Drug ID: DR00942
INTEDE Drug ID: DR0813
ACDINA Drug ID: D00311

Molecule(s) Related to This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Membrane copper amine oxidase (AOC3)	TT7HC21	AOC3_HUMAN	Modulator	[3]

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Drug-Metabolizing Enzyme (DME)

DME Name	DME ID	UniProt ID	Highest Status	REF
N-acetyltransferase 1 (NAT1)	DE7OAB3	ARY1_HUMAN	Approved	[4]
RNA cytidine acetyltransferase (hALP)	DEZV4AP	NAT10_HUMAN	Approved	[5]
N-acetyltransferase 2 (NAT2)	DER7TA0	ARY2_HUMAN	Approved	[4]

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The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule	Molecule Type	Gene Name	Liver	Colon	Kidney	Small Intestine
Membrane copper amine oxidase (AOC3)	DTT	AOC3	7.055	8.263	6.709	7.374
RNA cytidine acetyltransferase (hALP)	DME	NAT10	7.324	6.95	7.289	7.155
N-acetyltransferase 2 (NAT2)	DME	NAT2	8.344	7.451	3.154	8.135
N-acetyltransferase 1 (NAT1)	DME	NAT1	6.387	7.746	6.642	7.064

Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease

Chronic heart failure

ICD Disease Classification

BD1Z

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
Membrane copper amine oxidase (AOC3)	DTT	AOC3	8.36E-22	-1.03	-1.54
RNA cytidine acetyltransferase (hALP)	DME	NAT10	1.53E-02	1.17E-01	4.09E-01
N-acetyltransferase 2 (NAT2)	DME	NAT2	7.77E-14	-2.86E-01	-6.87E-01
N-acetyltransferase 1 (NAT1)	DME	NAT1	1.17E-06	2.81E-01	4.42E-01

Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1	Hydralazine FDA Label
2	URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7326).
3	Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services.
4	N-acetyltransferase 2 genotype-dependent N-acetylation of hydralazine in human hepatocytes. Drug Metab Dispos. 2017 Dec;45(12):1276-1281.
5	Prizidilol, an antihypertensive with precapillary vasodilator and beta-adrenoceptor blocking actions, in primary hypertension. Clin Pharmacol Ther. 1981 May;29(5):588-93.