Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DMUQ1DO)

• Drug Name: ITI-007 Drug Info

Indication

Disease Entry	ICD 11	Status	REF
Depression	6A70-6A7Z	Phase 3	[1]
Insomnia	7A00-7A0Z	Phase 3	[2]
Schizophrenia	6A20	Phase 3	[2]
Major depressive disorder	6A70.3	Phase 2	[1]

• Cross-matching ID:
  PubChem CID: 21302490
  CAS Number: CAS 313369-37-8
  TTD Drug ID: DMUQ1DO
  ACDINA Drug ID: D01228

Molecule(s) Related to This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
5-HT 2A receptor (HTR2A)	TTJQOD7	5HT2A_HUMAN	Antagonist	[3]
5-HT receptor (5HTR)	TT85JO3	NOUNIPROTAC	Antagonist	[1]
Serotonin transporter (SERT)	TT3ROYC	SC6A4_HUMAN	Antagonist	[3]

The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule	Molecule Type	Gene Name	Liver	Colon	Kidney	Small Intestine
5-HT 2A receptor (HTR2A)	DTT	HTR2A	4.84	4.904	4.652	4.129
Serotonin transporter (SERT)	DTT	SLC6A4	6.278	5.469	6.075	6.966

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

• ICD Disease Classification: 06 Mental, behavioural or neurodevelopmental disorder
• Disease Class: ICD-11: 6A20 Schizophrenia
• The Studied Tissue: Pre-frontal cortex
• The Studied Disease: Schizophrenia [ICD-11:6A20]

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
5-HT 2A receptor (HTR2A)	DTT	HTR2A	1.68E-01	-0.3	-0.14
5-HT 2A receptor (HTR2A)	DTT	HTR2A	5.59E-01	0.15	0.21
Serotonin transporter (SERT)	DTT	SLC6A4	7.90E-01	0.04	0.14
Serotonin transporter (SERT)	DTT	SLC6A4	4.98E-01	0.04	0.7

References

• [1] Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
• [2] ClinicalTrials.gov (NCT02469155) A Trial to Assess the Antipsychotic Efficacy of ITI-007 Over 6 Weeks of Treatment.
• [3] Clinical pipeline report, company report or official report of Intra-Cellular Therapies, Inc.