Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DMV1SOR)

Drug Name
AVP-786 Drug Info
Indication
Disease Entry ICD 11 Status REF
Alzheimer disease 8A20 Phase 3 [1]
Neurobehavioral disorder 8A00-8A0Z Phase 2 [2]
Schizophrenia 6A20 Phase 2 [1]
Pain MG30-MG3Z Phase 1 [3]
Cross-matching ID
PubChem CID
25052519
CAS Number
CAS 1079043-55-2
TTD Drug ID
DMV1SOR

Molecule(s) Related to This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Opioid receptor sigma 1 (OPRS1) TT5TPI6 SGMR1_HUMAN Modulator [3]
Serotonin transporter (SERT) TT3ROYC SC6A4_HUMAN Modulator [3]

The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule Molecule Type Gene Name Liver Colon Kidney Small Intestine
Opioid receptor sigma 1 (OPRS1) DTT SIGMAR1 7.092 5.716 5.411 6.434
Serotonin transporter (SERT) DTT SLC6A4 6.278 5.469 6.075 6.966
Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease Alzheimer disease
ICD Disease Classification 8A20
Molecule Name Molecule Type Gene Name p-value Fold-Change Z-score
Opioid receptor sigma 1 (OPRS1) DTT SIGMAR1 4.34E-01 0.03 0.26
Serotonin transporter (SERT) DTT SLC6A4 1.17E-01 0.07 0.59
Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1 Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
2 Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
3 Antitussives and substance abuse. Subst Abuse Rehabil. 2013 Nov 6;4:75-82.