Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DMWT8RI)

• Drug Name: PRX-105 Drug Info
• Synonyms: Acetylcholinesterase (poison intoxication, ProCellEx), Protalix/Hebrew University of Jerusalem; Acetylcholinesterase (poison intoxication, plant cell-expression), Protalix/Hebrew University of Jerusalem

Indication

Disease Entry	ICD 11	Status	REF
Poison intoxication	NE6Z	Phase 1	[1]

• Cross-matching ID: TTD Drug ID: DMWT8RI

Molecule(s) Related to This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Acetylcholinesterase (AChE)	TT1RS9F	ACES_HUMAN	Inhibitor	[2]

The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule	Molecule Type	Gene Name	Liver	Colon	Kidney	Small Intestine
Acetylcholinesterase (AChE)	DTT	ACHE	1.678	1.926	1.766	5.252

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

• The Studied Disease: Poison intoxication
• ICD Disease Classification: NE6Z

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
Acetylcholinesterase (AChE)	DTT	ACHE	6.39E-02	-1.07	-1.15

References

• [1] ClinicalTrials.gov (NCT01093859) An Exploratory Phase 1 Microdose Study of PRX-105. U.S. National Institutes of Health.
• [2] Preclinical and first-in-human evaluation of PRX-105, a PEGylated, plant-derived, recombinant human acetylcholinesterase-R. Toxicol Appl Pharmacol. 2015 Sep 15;287(3):202-9.