Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DMWZ6DK)

Drug Name

Roledumab Drug Info

Synonyms

DMATRIA; LFB-R593; R-297; R-593; Anti-D human monoclonal antibody, Laboratoire Francais du Fractionnement et des Biotechnologies; R297 antibody (hematological disease), LFB; R297 antibody (hematological disease), Laboratoire Francais du Fractionnement et des Biotechnologies; Anti-RhD antibody (hematological disease), LFB; Anti-rhesus D mAB (hematological disease), LFB

Indication

Disease Entry	ICD 11	Status	REF
Anemia	3A00-3A9Z	Phase 2/3	[1]

Cross-matching ID

TTD Drug ID: DMWZ6DK

Molecule(s) Related to This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Blood group Rh(D) polypeptide (RHD)	TTLCKI8	RHD_HUMAN	Not Available	[2]

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The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule	Molecule Type	Gene Name	Liver	Colon	Kidney	Small Intestine
Blood group Rh(D) polypeptide (RHD)	DTT	RHD	4.154	4.322	4.498	4.511

Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease

Anemia

ICD Disease Classification

3A00-3A9Z

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
Blood group Rh(D) polypeptide (RHD)	DTT	RHD	4.18E-02	0.64	1.13

Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1	ClinicalTrials.gov (NCT02287896) Pharmacokinetics and Safety of Roledumab, in RhD-negative Pregnant Women Carrying an RhD-positive Foetus. U.S. National Institutes of Health.
2	Pharmacokinetics and safety of roledumab, a novel human recombinant monoclonal anti-RhD antibody with an optimized Fc for improved engagement of FCgammaRIII, in healthy volunteers. Vox Sang. 2012 Oct;103(3):213-22.